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MedKoo Cat#: 564012 | Name: pBBG

Description:

WARNING: This product is for research use only, not for human or veterinary use.

pBBG is a glyoxalase 1 (Glo1) inhibitor, decreasing alcohol drinking in nondependent mice.

Chemical Structure

pBBG
pBBG
CAS#166038-00-2

Theoretical Analysis

MedKoo Cat#: 564012

Name: pBBG

CAS#: 166038-00-2

Chemical Formula: C27H38BrN3O6S

Exact Mass: 611.1665

Molecular Weight: 612.58

Elemental Analysis: C, 52.94; H, 6.25; Br, 13.04; N, 6.86; O, 15.67; S, 5.23

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
BrBzGCp2, BrBzGCp-2, BrBzGCp 2, p-BrBzGSH(Cp)2, pBrBzGSH(Cp)2, p-BrBzGSH(Cp)-2, pBBG, p-BBG, p BBG
IUPAC/Chemical Name
cyclopentyl N5-(3-((4-bromobenzyl)thio)-1-((2-(cyclopentyloxy)-2-oxoethyl)amino)-1-oxopropan-2-yl)glutaminate
InChi Key
QIFSPGPRHFNZNN-UHFFFAOYSA-N
InChi Code
InChI=1S/C27H38BrN3O6S/c28-19-11-9-18(10-12-19)16-38-17-23(26(34)30-15-25(33)36-20-5-1-2-6-20)31-24(32)14-13-22(29)27(35)37-21-7-3-4-8-21/h9-12,20-23H,1-8,13-17,29H2,(H,30,34)(H,31,32)
SMILES Code
O=C(C(NC(CCC(C(OC1CCCC1)=O)N)=O)CSCC2=CC=C(Br)C=C2)NCC(OC3CCCC3)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 612.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Barkley-Levenson AM, Lagarda FA, Palmer AA. Glyoxalase 1 (GLO1) Inhibition or Genetic Overexpression Does Not Alter Ethanol's Locomotor Effects: Implications for GLO1 as a Therapeutic Target in Alcohol Use Disorders. Alcohol Clin Exp Res. 2018 May;42(5):869-878. doi: 10.1111/acer.13623. Epub 2018 Apr 18. PubMed PMID: 29532486; PubMed Central PMCID: PMC5915917.