YH18968 | CAS#1632498-56-6 | GPR119 Agonist

MedKoo Cat#: 564007 | Name: YH18968

Description:

WARNING: This product is for research use only, not for human or veterinary use.

YH18968 is a GPR119 agonist, improving glucose tolerance and augmenting the glucose lowering effect. YH18968 augments the plasma level of active GLP-1 in normal mice in combination treatment with a dipeptidyl peptidase 4 (DPP-4) inhibitor.

Chemical Structure

YH18968

CAS#1632498-56-6

Theoretical Analysis

MedKoo Cat#: 564007

Name: YH18968

CAS#: 1632498-56-6

Chemical Formula: C27H28FN9O3

Exact Mass: 545.2299

Molecular Weight: 545.58

Elemental Analysis: C, 59.44; H, 5.17; F, 3.48; N, 23.11; O, 8.80

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

YH18968; YH-18968; YH 18968

IUPAC/Chemical Name

(S)-5-(3-Fluoro-4-(5-oxo-1-(tetrahydrofuran-3-yl)-1,5-dihydro-4H-1,2,4-triazol-4-yl)phenyl)-2-(4-(5-isopropyl1,2,4-oxadiazol-3-yl)piperazin-1-yl)nicotinonitrile

InChi Key

READJNFYOAOOFN-NRFANRHFSA-N

InChi Code

InChI=1S/C27H28FN9O3/c1-17(2)25-32-26(33-40-25)35-8-6-34(7-9-35)24-19(13-29)11-20(14-30-24)18-3-4-23(22(28)12-18)36-16-31-37(27(36)38)21-5-10-39-15-21/h3-4,11-12,14,16-17,21H,5-10,15H2,1-2H3/t21-/m0/s1

SMILES Code

N#CC1=C(N2CCN(C3=NOC(C(C)C)=N3)CC2)N=CC(C4=CC=C(N5C=NN([C@@H]6COCC6)C5=O)C(F)=C4)=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 545.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Han T, Lee BM, Park YH, Lee DH, Choi HH, Lee T, Kim H. YH18968, a Novel 1,2,4-Triazolone G-Protein Coupled Receptor 119 Agonist for the Treatment of Type 2 Diabetes Mellitus. Biomol Ther (Seoul). 2018 Mar 1;26(2):201-209. doi: 10.4062/biomolther.2018.011. PubMed PMID: 29495245; PubMed Central PMCID: PMC5839499.