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MedKoo Cat#: 581352 | Name: Domoprednate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Domoprednate is a synthetic glucocorticoid corticosteroid. The brand name is Stermonid.

Chemical Structure

Domoprednate
Domoprednate
CAS#66877-67-6

Theoretical Analysis

MedKoo Cat#: 581352

Name: Domoprednate

CAS#: 66877-67-6

Chemical Formula: C26H36O5

Exact Mass: 428.2563

Molecular Weight: 428.57

Elemental Analysis: C, 72.87; H, 8.47; O, 18.67

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Domoprednate; Domoprednatum; Ddomoprednato;
IUPAC/Chemical Name
(1R,4aS,4bS,10aR,10bS,11S,12aR)-1-acetyl-11-hydroxy-10a,12a-dimethyl-8-oxo-1,2,3,4,4a,4b,5,6,8,10a,10b,11,12,12a-tetradecahydrochrysen-1-yl butyrate
InChi Key
IYBYNRHXGXDDDS-QPVSRNMUSA-N
InChi Code
InChI=1S/C26H36O5/c1-5-7-22(30)31-26(16(2)27)12-6-8-20-19-10-9-17-14-18(28)11-13-24(17,3)23(19)21(29)15-25(20,26)4/h11,13-14,19-21,23,29H,5-10,12,15H2,1-4H3/t19-,20-,21-,23+,24-,25+,26-/m0/s1
SMILES Code
O=C1C=C[C@@]2([C@@H]3[C@@H](CCC2=C1)[C@@H]1CCC[C@@]([C@@]1(C[C@@H]3O)C)(C(=O)C)OC(=O)CCC)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 428.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Schmidt H, Hjorth N, Holm P. Domoprednate, a new nonhalogenated topical steroid: comparison to hydrocortisone butyrate. Dermatologica. 1987;175(3):145-7. PubMed PMID: 3653463. 2: Christiansen JV, Foged E, Holm P, Jørgensen AS, Reymann F. The treatment of psoriasis with 0.1% domoprednate (a D-homocorticosteroid) and 0.1% betamethasone valerate ointment. A double-blind, randomized trial. Dermatologica. 1985;170(4):195-8. PubMed PMID: 3888709. 3: Serup J, Holm P. Domoprednate (Stermonid), a topical D-homocorticosteroid, skin atrophy and telangiectasia. A double-blind, randomized comparison with hydrocortisone butyrate, betamethasone valerate, clobetasole propionate and placebo. Dermatologica. 1985;170(4):189-94. PubMed PMID: 3888708. 4: Schmidt H, Hjorth N, Holm P. A randomized trial on the D-homosteroid domoprednate (Ro 12-7024) in the treatment of dermatoses. Dermatologica. 1984;168(3):127-30. PubMed PMID: 6370748.

View History

MRS2279

MRS2279