Fce 21258 | 71934-91-3 | xxxx

MedKoo Cat#: 581345 | Name: Fce 21258

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fce 21258 is used to stimulate the adenylate cyclase of synovial fluid macrophages.

Chemical Structure

Fce 21258

CAS#71934-91-3

Theoretical Analysis

MedKoo Cat#: 581345

Name: Fce 21258

CAS#: 71934-91-3

Chemical Formula: C21H32O4

Exact Mass: 348.2301

Molecular Weight: 348.48

Elemental Analysis: C, 72.38; H, 9.26; O, 18.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Fce 21258; Ddh-carbo pgl2;

IUPAC/Chemical Name

(3aS-(2E,3aalpha,4alpha(R*),5beta,6aalpha))-5-(Hexahydro-5-hydroxy-4-(3-hydroxy-1-octynyl)-2(1H)-pentalenylidene)pentanoic acid

InChi Key

KYEMFDPJTPLZIP-CXBSDXPTSA-N

InChi Code

InChI=1S/C21H32O4/c1-2-3-4-8-17(22)10-11-18-19-13-15(7-5-6-9-21(24)25)12-16(19)14-20(18)23/h7,16-20,22-23H,2-6,8-9,12-14H2,1H3,(H,24,25)/b15-7+/t16-,17-,18+,19-,20+/m0/s1

SMILES Code

O=C(O)CCC/C=C1C[C@@]2([H])C[C@@H](O)[C@H](C#C[C@@H](O)CCCCC)[C@@]2([H])C\1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 348.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Elliott GR, Swaak A, Bonta IL. The adenylate cyclase of rheumatoid synovial fluid macrophages is more sensitive for dl-5E, 19,14-di dehydro-carbo-prostacyclin, a stable prostacyclin analogue, than for prostaglandin E2. Prostaglandins Leukot Essent Fatty Acids. 1988 Aug;33(2):105-10. PubMed PMID: 2845436. 2: Adolfs MJ, Bonta IL. Plasticity of prostaglandin E2 receptor in human macrophages and the ternary complex of adenylate cyclase. Adv Prostaglandin Thromboxane Leukot Res. 1987;17A:459-62. PubMed PMID: 2889337. 3: Adolfs MJ, Fieren MW, Bonta IL. Infectious-inflammatory changes in cyclic AMP levels and in their regulation by prostaglandins in human peritoneal macrophages. Prostaglandins Leukot Med. 1985 May;18(2):217-26. PubMed PMID: 2989936. 4: Morley J, Page CP, Paul W, Mongelli N, Ceserani R, Gandolfi C. A comparative study of PGI2 and two analogues (FCE 21292 and FCE 21258) in vitro and in vivo. Prostaglandins Leukot Med. 1983 Aug;11(4):391-9. PubMed PMID: 6353424.