DSP-6952 | CAS#1184661-33-3 | 5-HT4 Partial Agonist

MedKoo Cat#: 563992 | Name: DSP-6952

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DSP-6952 is a 5-HT4 receptor partial agonist, inhibiting visceral hypersensitivity and ameliorating gastrointestinal dysfunction.

Chemical Structure

DSP-6952

CAS#1184661-33-3

Theoretical Analysis

MedKoo Cat#: 563992

Name: DSP-6952

CAS#: 1184661-33-3

Chemical Formula: C21H36BrClN4O7

Exact Mass: 570.1456

Molecular Weight: 571.89

Elemental Analysis: C, 44.10; H, 6.35; Br, 13.97; Cl, 6.20; N, 9.80; O, 19.58

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

DSP-6952; DSP6952; DSP 6952

IUPAC/Chemical Name

(S)-4-Amino-5-chloro-N-((4-((1-(2-hydroxyacetyl)piperidin-4-yl)methyl)morpholin-2-yl)methyl)-2-methoxybenzamide Hydrobromide dihydrate

InChi Key

PNMMVYQNYDDJNF-CFZZCFLMSA-N

InChi Code

InChI=1S/C21H31ClN4O5.BrH.2H2O/c1-30-19-9-18(23)17(22)8-16(19)21(29)24-10-15-12-25(6-7-31-15)11-14-2-4-26(5-3-14)20(28)13-27;;;/h8-9,14-15,27H,2-7,10-13,23H2,1H3,(H,24,29);1H;2*1H2/t15-;;;/m0.../s1

SMILES Code

O=C(NC[C@H]1CN(CC2CCN(C(CO)=O)CC2)CCO1)C3=CC(Cl)=C(N)C=C3OC.[H]Br.[H]O[H].[H]O[H]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 571.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Mine Y, Itakura T, Oku S, Asada R, Shimizu I. DSP-6952, a novel 5-HT(4) receptor partial agonist, inhibits visceral hypersensitivity and ameliorates gastrointestinal dysfunction in experimental animals. Eur J Pharmacol. 2018 May 5;826:123-132. doi: 10.1016/j.ejphar.2018.02.005. Epub 2018 Feb 9. PubMed PMID: 29428470. 2: Tsubouchi T, Kunimatsu T, Tsujimoto S, Kiyoshi A, Katsura Y, Oku S, Chihara K, Mine Y, Yamada T, Shimizu I, Bando K. The in vitro pharmacology and non-clinical cardiovascular safety studies of a novel 5-HT(4) receptor agonist, DSP-6952. Eur J Pharmacol. 2018 May 5;826:96-105. doi: 10.1016/j.ejphar.2018.02.037. Epub 2018 Mar 1. PubMed PMID: 29501863.