IUPAC/Chemical Name
(4R)-4-(2,3,4,6,6abeta,7,8,9,9aalpha,9bbeta-Decahydro-6abeta-methyl-3-oxo-1H-cyclopenta(f)quinolin-7beta-yl)valeric acid
InChi Key
YHBFMULEUYRINA-VVAOUYSKSA-N
InChi Code
InChI=1S/C18H27NO3/c1-11(3-8-17(21)22)13-5-6-14-12-4-7-16(20)19-15(12)9-10-18(13,14)2/h9,11-14H,3-8,10H2,1-2H3,(H,19,20)(H,21,22)/t11-,12?,13+,14?,18+/m1/s1
SMILES Code
C[C@@H]([C@@H]1CCC2C3CCC(NC3=CC[C@]21C)=O)CCC(O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
305.42
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Nishimaki-Mogami T, Suzuki K, Okochi E, Takahashi A. Bezafibrate and clofibric
acid are novel inhibitors of phosphatidylcholine synthesis via the methylation of
phosphatidylethanolamine. Biochim Biophys Acta. 1996 Nov 11;1304(1):11-20. PubMed
PMID: 8944746.
2: Hayashi Y, Toyoda K, Imazawa T, Sato H, Okamiya H, Kurokawa Y, Takahashi J,
Mogami-Nishimaki T, Hayakawa S. Peroxisome proliferation of hepatocytes in rats
by a microbial degradation product of cholic acid,
4-(decahydro-6-methyl-3-oxocyclopenta(f)quinoline-7-yl)valeric acid. Exp Toxicol
Pathol. 1994 Jul;46(2):127-32. PubMed PMID: 7987070.
3: Nishimaki-Mogami T, Takahashi A, Hayashi Y. Activation of a
peroxisome-proliferating catabolite of cholic acid to its CoA ester. Biochem J.
1993 Nov 15;296 ( Pt 1):265-70. PubMed PMID: 8250853; PubMed Central PMCID:
PMC1137683.
4: Nishimaki-Mogami T, Takahashi A, Toyoda K, Hayashi Y. Induction of peroxisomal
beta-oxidation by a microbial catabolite of cholic acid in rat liver and cultured
rat hepatocytes. Biochem J. 1993 Oct 1;295 ( Pt 1):217-20. PubMed PMID: 8216219;
PubMed Central PMCID: PMC1134841.