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MedKoo Cat#: 563956 | Name: RS-102221 HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

RS-102221 HCl is a highly potent, selective 5-HT2C receptor antagonist.

Chemical Structure

RS-102221 HCl
RS-102221 HCl
CAS#187397-18-8

Theoretical Analysis

MedKoo Cat#: 563956

Name: RS-102221 HCl

CAS#: 187397-18-8

Chemical Formula: C27H32ClF3N4O7S

Exact Mass: 648.1632

Molecular Weight: 649.08

Elemental Analysis: C, 49.96; H, 4.97; Cl, 5.46; F, 8.78; N, 8.63; O, 17.25; S, 4.94

Price and Availability

Size Price Availability Quantity
10mg USD 355.00
50mg USD 1,025.00
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Related CAS #
No Data
Synonym
RS-102221 HCl; RS102221 HCl; RS 102221 HCl
IUPAC/Chemical Name
N-[5-[5-(2,4-Dioxo-1,3,8-triazaspiro[4.5]decan-8-yl)pentanoyl]-2,4-dimethoxyphenyl]-4-(trifluoromethyl)benzenesulfonamide hydrochloride
InChi Key
SZJZEJZLRDIHPB-UHFFFAOYSA-N
InChi Code
InChI=1S/C27H31F3N4O7S.ClH/c1-40-22-16-23(41-2)20(33-42(38,39)18-8-6-17(7-9-18)27(28,29)30)15-19(22)21(35)5-3-4-12-34-13-10-26(11-14-34)24(36)31-25(37)32-26;/h6-9,15-16,33H,3-5,10-14H2,1-2H3,(H2,31,32,36,37);1H
SMILES Code
O=S(C1=CC=C(C(F)(F)F)C=C1)(NC2=CC(C(CCCCN(CC3)CCC3(NC(N4)=O)C4=O)=O)=C(OC)C=C2OC)=O.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 649.08 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Chronic treatments with a 5-HT4 receptor agonist decrease amyloid pathology in the entorhinal cortex and learning and memory deficits in the 5xFAD mouse model of Alzheimer's disease. Neuropharmacology. 2017 Nov;126:128-141. doi: 10.1016/j.neuropharm.2017.08.031. Epub 2017 Aug 26. PMID: 28844596. 10: Freret T, Lelong-Boulouard V, Lecouflet P, Hamidouche K, Dauphin F, Boulouard M. Co-modulation of an allosteric modulator of nicotinic receptor- cholinesterase inhibitor (galantamine) and a 5-HT4 receptor agonist (RS-67333): effect on scopolamine-induced memory deficit in the mouse. Psychopharmacology (Berl). 2017 Aug;234(15):2365-2374. doi: 10.1007/s00213-017-4664-z. Epub 2017 Jun 19. PMID: 28631100. 11: Nasehi M, Rostam-Nezhad E, Ebrahimi-Ghiri M, Zarrindast MR. Interaction between hippocampal serotonin and cannabinoid systems in reactivity to spatial and object novelty detection. Behav Brain Res. 2017 Jan 15;317:272-278. doi: 10.1016/j.bbr.2016.09.059. Epub 2016 Sep 26. 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