MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 563941 | Name: IHR-SAHA

Description:

WARNING: This product is for research use only, not for human or veterinary use.

IHR-SAHA is a dual SMO-HDAC antagonist, retaining similar specificity for SAHA-targeted HDACs. IHR-SAHA disables deviant Hedgehog signaling and prevents GLI binding to DNA.

Chemical Structure

IHR-SAHA
IHR-SAHA
CAS#NONE

Theoretical Analysis

MedKoo Cat#: 563941

Name: IHR-SAHA

CAS#: NONE

Chemical Formula: C28H27Cl3N4O5

Exact Mass: 604.1047

Molecular Weight: 605.90

Elemental Analysis: C, 55.51; H, 4.49; Cl, 17.55; N, 9.25; O, 13.20

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
IHR-SAHA ; IHRSAHA ; IHR SAHA
IUPAC/Chemical Name
N1-(4-Chloro-3-((4-(2,5-dichlorobenzamido)phenyl)carbamoyl)phenyl)-N8-hydroxyoctanediamide
InChi Key
UMHLABRHRMBWTO-UHFFFAOYSA-N
InChi Code
InChI=1S/C28H27Cl3N4O5/c29-17-7-13-23(30)21(15-17)27(38)33-18-8-10-19(11-9-18)34-28(39)22-16-20(12-14-24(22)31)32-25(36)5-3-1-2-4-6-26(37)35-40/h7-16,40H,1-6H2,(H,32,36)(H,33,38)(H,34,39)(H,35,37)
SMILES Code
O=C(NC1=CC=C(Cl)C(C(NC2=CC=C(NC(C3=CC(Cl)=CC=C3Cl)=O)C=C2)=O)=C1)CCCCCCC(NO)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Synthetic combinatorial therapeutic agents such as IHR-SAHA that a priori disable cancer drivers and anticipated mechanisms of drug resistance could extend the duration of disease remission, and provide an alternative clinical development path for realizing combinatorial therapy modalities.

Preparing Stock Solutions

The following data is based on the product molecular weight 605.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Fan CW, Yarravarapu N, Shi H, Kulak O, Kim J, Chen C, Lum L. A synthetic combinatorial approach to disabling deviant Hedgehog signaling. Sci Rep. 2018 Jan 18;8(1):1133. doi: 10.1038/s41598-018-19408-9. PubMed PMID: 29348431; PubMed Central PMCID: PMC5773580.