MedKoo Cat#: 563924 | Name: PNR-7-02

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PNR-7-02 is an inhibitor of human DNA polymerase eta (Polη).

Chemical Structure

PNR-7-02
PNR-7-02
CAS#1633660-76-0

Theoretical Analysis

MedKoo Cat#: 563924

Name: PNR-7-02

CAS#: 1633660-76-0

Chemical Formula: C24H16ClN3O2S

Exact Mass: 445.0652

Molecular Weight: 445.92

Elemental Analysis: C, 64.64; H, 3.62; Cl, 7.95; N, 9.42; O, 7.18; S, 7.19

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
PNR-7-02; PNR702; PNR 7 02; PNR-702; PNR7-02; PNR 7-02; PNR-7 02
IUPAC/Chemical Name
5-((5-Chloro-1-(naphthalen-2-ylmethyl)-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
InChi Key
YNPDEEPROJUWCY-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H16ClN3O2S/c25-18-7-8-21-19(11-18)17(10-20-22(29)26-24(31)27-23(20)30)13-28(21)12-14-5-6-15-3-1-2-4-16(15)9-14/h1-11,13H,12H2,(H2,26,27,29,30,31)
SMILES Code
O=C(/C(C(N1)=O)=C\C2=CN(CC3=CC=C4C=CC=CC4=C3)C5=C2C=C(Cl)C=C5)NC1=S
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 445.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zafar MK, Maddukuri L, Ketkar A, Penthala NR, Reed MR, Eddy S, Crooks PA, Eoff RL. A Small-Molecule Inhibitor of Human DNA Polymerase η Potentiates the Effects of Cisplatin in Tumor Cells. Biochemistry. 2018 Feb 20;57(7):1262-1273. doi: 10.1021/acs.biochem.7b01176. Epub 2018 Jan 30. PubMed PMID: 29345908.