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MedKoo Cat#: 563918 | Name: JCC76

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JCC76 is a selective inhibitor of heat shock protein 27 (Hsp27). JCC76 inhibits the proliferation of human epidermal growth factor 2 (Her2).

Chemical Structure

JCC76
JCC76
CAS#1021926-22-6

Theoretical Analysis

MedKoo Cat#: 563918

Name: JCC76

CAS#: 1021926-22-6

Chemical Formula: C24H32N2O4S

Exact Mass: 444.2083

Molecular Weight: 444.59

Elemental Analysis: C, 64.84; H, 7.26; N, 6.30; O, 14.39; S, 7.21

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
JCC76; JCC-76; JCC 76
IUPAC/Chemical Name
N-[3-[(2,5-Dimethylphenyl)methoxy]-4-[methyl(methylsulfonyl)amino]phenyl]cyclohexanecarboxamide
InChi Key
NLBGXSHIKISRHR-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H32N2O4S/c1-17-10-11-18(2)20(14-17)16-30-23-15-21(12-13-22(23)26(3)31(4,28)29)25-24(27)19-8-6-5-7-9-19/h10-15,19H,5-9,16H2,1-4H3,(H,25,27)
SMILES Code
O=C(C1CCCCC1)NC2=CC=C(N(C)S(=O)(C)=O)C(OCC3=CC(C)=CC=C3C)=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 444.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhao A, Zheng Q, Orahoske CM, Idippily ND, Ashcraft MM, Quamine A, Su B. Synthesis and biological evaluation of anti-cancer agents that selectively inhibit Her2 over-expressed breast cancer cell growth via down-regulation of Her2 protein. Bioorg Med Chem Lett. 2018 Feb 15;28(4):727-731. doi: 10.1016/j.bmcl.2018.01.016. Epub 2018 Jan 12. PubMed PMID: 29352646. 2: Voggu RR, Alagandula R, Zhou X, Su B, Zhong B, Guo B. A rapid LC-MS/MS method for quantification of CSUOH0901, a novel antitumor agent, in rat plasma. Biomed Chromatogr. 2015 May;29(5):797-802. doi: 10.1002/bmc.3365. Epub 2014 Nov 26. PubMed PMID: 25424731. 3: Cai X, Zhong B, Su B, Xu S, Guo B. Development and validation of a rapid LC-MS/MS method for the determination of JCC76, a novel antitumor agent for breast cancer, in rat plasma and its application to a pharmacokinetics study. Biomed Chromatogr. 2012 Sep;26(9):1118-24. doi: 10.1002/bmc.1757. Epub 2011 Dec 27. PubMed PMID: 22213194.