Synonym
Phtiobuzone; V-6133; V 6133; V6133.
IUPAC/Chemical Name
Hydrazinecarbothioamide, 2,2'-(1-(1-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethyl)-1,2-ethanediylidene)bis-
InChi Key
OPXFZJLGAZHBMA-BUOGMGTNSA-N
InChi Code
InChI=1S/C14H15N7O2S2/c1-7(10(18-20-14(16)25)6-17-19-13(15)24)21-11(22)8-4-2-3-5-9(8)12(21)23/h2-7H,1H3,(H3,15,19,24)(H3,16,20,25)/b17-6+,18-10+
SMILES Code
CC(C(/C=N/NC(N)=S)=N/NC(N)=S)N(C(C1=C2C=CC=C1)=O)C2=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
377.44
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: 1: Yang YJ, Zhao JH, Pan XD, Zhang PC. Synthesis and antiviral activity of phthiobuzone analogues. Chem Pharm Bull (Tokyo). 2010 Feb;58(2):208-11. PubMed PMID: 20118580.
2: Wang GX, Wang L, Zhao ZZ, Tao PZ, Wang SQ. [Synthesis of optically active (R)- and (S)-tai-ding-an(TDA) and their anti-HSV activity evaluation]. Yao Xue Xue Bao. 1996;31(11):831-6. Chinese. PubMed PMID: 9863253.
3: Wang L, Yang HM, Zhao ZZ. [Studies on antiviral agents: synthesis of tai-ding-an analogs]. Yao Xue Xue Bao. 1994;29(6):427-32. Chinese. PubMed PMID: 7992623.
4: Chen ZJ, Liu WG, Song JZ. [Experimental studies of 9-(1, 3-dihydroxy-2-propoxymethyl)-guanine(DHPG) against herpes simplex virus]. Yao Xue Xue Bao. 1989;24(5):331-4. Chinese. PubMed PMID: 2481939.
5: Jiang XJ, Zhao ZZ. [Synthesis of analogs of tai-ding-an, a new drug for treatment of Chlamydozoa trachomatis]. Yao Xue Xue Bao. 1987 Apr;22(4):308-11. Chinese. PubMed PMID: 2825467.
6: Chen ZJ, Gao CF, Liu WG, Song JZ. [The efficacy of tai-ding-an on experimental herpetic keratitis in rabbits]. Yao Xue Xue Bao. 1986 Dec;21(12):928-30. Chinese. PubMed PMID: 3035866.
7: Yin MB, Gao YJ, Xia LJ, Liu YY, Wang L, Chen M, Yang HM, Zhao ZZ. [Comparative studies on antiviral activity of several TDA analogs against HSV-2]. Yao Xue Xue Bao. 1986 Sep;21(9):657-62. Chinese. PubMed PMID: 3033992.
8: Chen HS, Li JH, Teng L, Cai SY, Wang L, Zhao ZZ. [The efficacy of tai-ding-an on the inhibition of HSV-I skin infections in guinea pigs]. Yao Xue Xue Bao. 1986 Apr;21(4):252-5. Chinese. PubMed PMID: 3788592.
9: Yin MB. [Inhibitory effect of tai-ding-an on DNA and protein synthesis of herpes simplex virus type 2 (HSV-2)]. Zhonghua Yi Xue Za Zhi. 1985 Oct;65(10):587-9. Chinese. PubMed PMID: 3008965.
10: Hou MQ, Wang ZS, Li ZX. [Studies on the inclusion compound of dioxane with phtiobuzone (author's transl)]. Yao Xue Xue Bao. 1981 Apr;16(4):317-9. Chinese. PubMed PMID: 7257820.
