TB-2-081 | CAS#451470-55-6 | IL-6 Antagonist

MedKoo Cat#: 563908 | Name: TB-2-081

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TB-2-081 is a antagonist of IL-6 signaling.

Chemical Structure

TB-2-081

CAS#451470-55-6

Theoretical Analysis

MedKoo Cat#: 563908

Name: TB-2-081

CAS#: 451470-55-6

Chemical Formula: C25H32O6

Exact Mass: 428.2199

Molecular Weight: 428.53

Elemental Analysis: C, 70.07; H, 7.53; O, 22.40

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

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Synonym

TB-2-081; TB2081; TB 2 081; TB-2081; TB2-081; TB 2-081; TB-2 081

IUPAC/Chemical Name

3-O-Formyl-20R,21-epoxyresibufogenin

InChi Key

CMYYMVGNLZUIOQ-AYFUEPLASA-N

InChi Code

InChI=1S/C25H32O6/c1-22-8-5-15(28-13-26)11-14(22)3-4-17-16(22)6-9-23(2)18(12-19-25(17,23)30-19)24-10-7-20(27)29-21(24)31-24/h7,10,13-19,21H,3-6,8-9,11-12H2,1-2H3/t14-,15+,16+,17-,18-,19-,21+,22+,23-,24-,25-/m1/s1

SMILES Code

O=CO[C@@H]1C[C@@H](CC[C@@H]2[C@@H]3CC[C@@]4(C)[C@]2(O5)[C@H]5C[C@H]4[C@]67C=CC(O[C@H]6O7)=O)[C@]3(C)CC1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 428.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Remeniuk B, King T, Sukhtankar D, Nippert A, Li N, Li F, Cheng K, Rice KC, Porreca F. Disease modifying actions of interleukin-6 blockade in a rat model of bone cancer pain. Pain. 2018 Apr;159(4):684-698. doi: 10.1097/j.pain.0000000000001139. PubMed PMID: 29300279; PubMed Central PMCID: PMC5911943. 2: Boos TL, Cheng K, Greiner E, Deschamps JR, Jacobson AE, Rice KC. Configurational reassignment and improved preparation of the competitive IL-6 receptor antagonist 20R,21R-epoxyresibufogenin-3-formate. J Nat Prod. 2012 Apr 27;75(4):661-8. doi: 10.1021/np2008957. Epub 2012 Feb 23. PubMed PMID: 22360661; PubMed Central PMCID: PMC3351795. 3: Vardanyan M, Melemedjian OK, Price TJ, Ossipov MH, Lai J, Roberts E, Boos TL, Deschamps JR, Jacobson AE, Rice KC, Porreca F. Reversal of pancreatitis-induced pain by an orally available, small molecule interleukin-6 receptor antagonist. Pain. 2010 Nov;151(2):257-65. doi: 10.1016/j.pain.2010.05.022. Epub 2010 Jul 4. PubMed PMID: 20599324; PubMed Central PMCID: PMC3313485. 4: Kino T, Boos TL, Sulima A, Siegel EM, Gold PW, Rice KC, Chrousos GP. 3-O-Formyl-20R,21-epoxyresibufogenin suppresses IL-6-type cytokine actions by targeting the glycoprotein 130 subunit: potential clinical implications. J Allergy Clin Immunol. 2007 Aug;120(2):437-44. Epub 2007 Apr 23. PubMed PMID: 17451794. 5: Hayashi M, Rho MC, Fukami A, Enomoto A, Nonaka S, Sekiguchi Y, Yanagisawa T, Yamashita A, Nogawa T, Kamano Y, Komiyama K. Biological activity of a novel nonpeptide antagonist to the interleukin-6 receptor 20S,21-epoxy-resibufogenin-3-formate. J Pharmacol Exp Ther. 2002 Oct;303(1):104-9. PubMed PMID: 12235239. 6: Li W, Shi X, Wang L, Guo T, Wei T, Cheng K, Rice KC, Kingery WS, Clark JD. Epidermal adrenergic signaling contributes to inflammation and pain sensitization in a rat model of complex regional pain syndrome. Pain. 2013 Aug;154(8):1224-36. doi: 10.1016/j.pain.2013.03.033. Epub 2013 Apr 12. PubMed PMID: 23718987; PubMed Central PMCID: PMC3713848.

View History

Description:

Chemical Structure

Theoretical Analysis

Price and Availability

Preparing Stock Solutions

View History

MDK-3046

GSK-3008348

Hexyldecyl myristoyl methylaminopropionate

NBD-14136

MRL-299

PSMA−DB

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