ZYZ-803 | CAS#2088043-51-8 | H2S-NO-releasing hybrid

MedKoo Cat#: 563902 | Name: ZYZ-803

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ZYZ-803 is a slow H2S-NO-releasing hybrid, attenuating cardiac dysfunction after heart failure.

Chemical Structure

ZYZ-803

CAS#2088043-51-8

Theoretical Analysis

MedKoo Cat#: 563902

Name: ZYZ-803

CAS#: 2088043-51-8

Chemical Formula: C20H23N3O6S

Exact Mass: 433.1308

Molecular Weight: 433.48

Elemental Analysis: C, 55.42; H, 5.35; N, 9.69; O, 22.15; S, 7.40

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

ZYZ-803; ZYZ 803; ZYZ803

IUPAC/Chemical Name

3-(((N-(tert-Butoxycarbonyl)-S-(prop-2-yn-1-yl)cysteinyl)oxy)methyl)-4-phenyl-1,2,5-oxadiazole 2-oxide

InChi Key

SXEWNJSLDYZELF-HNNXBMFYSA-N

InChi Code

InChI=1S/C20H23N3O6S/c1-5-11-30-13-15(21-19(25)28-20(2,3)4)18(24)27-12-16-17(22-29-23(16)26)14-9-7-6-8-10-14/h1,6-10,15H,11-13H2,2-4H3,(H,21,25)/t15-/m0/s1

SMILES Code

O=C(OCC1=[N+]([O-])ON=C1C2=CC=CC=C2)[C@H](CSCC#C)NC(OC(C)(C)C)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 433.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Wu D, Hu Q, Xiong Y, Zhu D, Mao Y, Zhu YZ. Novel H(2)S-NO hybrid molecule (ZYZ-803) promoted synergistic effects against heart failure. Redox Biol. 2018 May;15:243-252. doi: 10.1016/j.redox.2017.11.020. Epub 2017 Dec 14. PubMed PMID: 29288927; PubMed Central PMCID: PMC5975222. 2: Hu Q, Wu D, Ma F, Yang S, Tan B, Xin H, Gu X, Chen X, Chen S, Mao Y, Zhu YZ. Novel Angiogenic Activity and Molecular Mechanisms of ZYZ-803, a Slow-Releasing Hydrogen Sulfide-Nitric Oxide Hybrid Molecule. Antioxid Redox Signal. 2016 Sep 10;25(8):498-514. doi: 10.1089/ars.2015.6607. Epub 2016 Jun 29. PubMed PMID: 27174595. 3: Wu D, Hu Q, Ma F, Zhu YZ. Vasorelaxant Effect of a New Hydrogen Sulfide-Nitric Oxide Conjugated Donor in Isolated Rat Aortic Rings through cGMP Pathway. Oxid Med Cell Longev. 2016;2016:7075682. doi: 10.1155/2016/7075682. Epub 2015 Nov 9. PubMed PMID: 26635911; PubMed Central PMCID: PMC4655279.