Synonym
AZ1; AZ-1; AZ 1; AZ1; AZ1 USP25/28 inhibitor
IUPAC/Chemical Name
2-(5-Bromo-2-(4-fluoro-3-(trifluoromethyl)benzyloxy)benzylamino)ethanol
InChi Key
ITHSFXDGKQYOED-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H16BrF4NO2/c18-13-2-4-16(12(8-13)9-23-5-6-24)25-10-11-1-3-15(19)14(7-11)17(20,21)22/h1-4,7-8,23-24H,5-6,9-10H2
SMILES Code
FC(C1=CC(COC2=CC=C(Br)C=C2CNCCO)=CC=C1F)(F)F
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
422.22
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Song Y, Wang L, Zheng Y, Jia L, Li C, Chao K, Li L, Sun S, Wei Y, Ge Y, Yang
Y, Zhu L, Zhang Y, Zhao J. Deubiquitinating enzyme USP28 inhibitor AZ1 alone and
in combination with cisplatin for the treatment of non-small cell lung cancer.
Apoptosis. 2024 Oct;29(9-10):1793-1809. doi: 10.1007/s10495-024-02008-6. Epub
2024 Sep 2. PMID: 39222275; PMCID: PMC11416398.
2: Aoto H, Miyake Y, Nakamura M, Tajima S. Genomic organization of the mouse AZ1
gene that encodes the protein localized to preacrosomes of spermatids. Genomics.
1997 Feb 15;40(1):138-41. doi: 10.1006/geno.1996.4546. PMID: 9070930.
3: Zhang AL, Wu XY, Li JQ, Zhang Z, Zhang H. Molecular characterization, tissue
expression and nucleotide variation of the porcine AZ1 gene. Gene. 2012 Jun
10;501(1):79-84. doi: 10.1016/j.gene.2012.01.010. Epub 2012 Jan 30. PMID:
22310384.
4: Servín-Garcidueñas LE, Martínez-Romero E. Draft Genome Sequence of the
Sulfolobales Archaeon AZ1, Obtained through Metagenomic Analysis of a Mexican
Hot Spring. Genome Announc. 2014 Mar 6;2(2):e00164-14. doi:
10.1128/genomeA.00164-14. PMID: 24604657; PMCID: PMC3945513.
5: Deljou A, Goudarzi S. Green Extracellular Synthesis of the Silver
Nanoparticles Using Thermophilic Bacillus Sp. AZ1 and its Antimicrobial
Activity Against Several Human Pathogenetic Bacteria. Iran J Biotechnol. 2016
Jun;14(2):25-32. doi: 10.15171/ijb.1259. PMID: 28959323; PMCID: PMC5435029.
6: Pu Q, Wiel E, Corseaux D, Bordet R, Azrin MA, Ezekowitz MD, Lund N, Jude B,
Vallet B. Beneficial effect of glycoprotein IIb/IIIa inhibitor (AZ-1) on
endothelium in Escherichia coli endotoxin-induced shock. Crit Care Med. 2001
Jun;29(6):1181-8. doi: 10.1097/00003246-200106000-00019. PMID: 11395599.
