Synonym
DC 015; DC015; DC-015; DL-028; DL 028; DL028;
IUPAC/Chemical Name
3-((4-(2-Methoxyphenyl)piperazin-1-yl)methyl)-2,3-dihydroimidazo(1,2-c)quinazolin-5(6H)-one
InChi Key
FUCGAUZSWYLMRK-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H25N5O2/c1-29-20-9-5-4-8-19(20)26-12-10-25(11-13-26)15-16-14-23-21-17-6-2-3-7-18(17)24-22(28)27(16)21/h2-9,16H,10-15H2,1H3,(H,24,28)
SMILES Code
O=C1NC2=C(C=CC=C2)C3=NCC(CN4CCN(C5=CC=CC=C5OC)CC4)N13
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
391.47
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Huang YT, Lin LC, Chern JW, Lin HC, Hong CY. Portal hypotensive effects of combined terlipressin and DL-028, a synthetic alpha 1 adrenoceptor antagonist administration on anesthetized portal hypertensive rats. Liver. 1999 Apr;19(2):129-34. PubMed PMID: 10220743.
2: Huang YT, Wu HL, Chern JW, Lin HC, Hong CY. Hemodynamic effects of 8-day DL-028 and octreotide administration in rats with portal hypertension. Scand J Gastroenterol. 1998 Dec;33(12):1303-9. PubMed PMID: 9930395.
3: Peng IH, Sheu JR, Chern JW, Lee YM, Yen MH. Antihypertensive and Hypolipidemic Effects of DC-015, a Novel, Potent and Specific alpha(1)-Adrenoceptor Antagonist: Comparison with Prazosin in Spontaneously Hypertensive Rats. J Biomed Sci. 1996 Apr;3(2):108-116. PubMed PMID: 11725091.
4: Sheu JR, Peng IH, Lee YM, Yen MH. Effects of DC-015, a novel potent and selective alpha 1-adrenoceptor antagonist on plasma lipid and vascular reactivity in hyperlipidaemic rats. Clin Exp Pharmacol Physiol. 1996 Mar;23(3):207-13. PubMed PMID: 8934609.
5: Yen MH, Sheu JR, Peng IH, Lee YM, Chern JW. Pharmacological activity of DC-015, a novel potent and selective alpha 1-adrenoceptor antagonist. J Pharm Pharmacol. 1996 Jan;48(1):90-5. PubMed PMID: 8722503.
6: Yen MH, Lee YM, Huang TF, Sheu JR. Effect of DC-015, a novel potent and selective alpha 1-adrenoceptor antagonist, comparison with prazosin on noradrenaline-induced platelet aggregation. Chin J Physiol. 1995;38(2):93-8. Erratum in: Chin J Physiol 1995;38(3):200. PubMed PMID: 8697903.
