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MedKoo Cat#: 563848 | Name: Thiazolidinedione-8

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Thiazolidinedione-8 is an antibiofilm agent, disturbing symbiotic balance between C. albicans and S. mutans in dual species biofilm.

Chemical Structure

Thiazolidinedione-8
Thiazolidinedione-8
CAS#2243464-07-3

Theoretical Analysis

MedKoo Cat#: 563848

Name: Thiazolidinedione-8

CAS#: 2243464-07-3

Chemical Formula: C10H15NO2S

Exact Mass: 213.0823

Molecular Weight: 213.30

Elemental Analysis: C, 56.31; H, 7.09; N, 6.57; O, 15.00; S, 15.03

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Thiazolidinedione-8; Thiazolidinedione8; Thiazolidinedione 8; TZD-8; TZD8; TZD 8; S-8; S8; S 8
IUPAC/Chemical Name
5(Z)-Heptylidene-thiazolidine-2,4-dione
InChi Key
SEBONXXIHGKXBF-FPLPWBNLSA-N
InChi Code
InChI=1S/C10H15NO2S/c1-2-3-4-5-6-7-8-9(12)11-10(13)14-8/h7H,2-6H2,1H3,(H,11,12,13)/b8-7-
SMILES Code
O=C(NC/1=O)SC1=C/CCCCCC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 213.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Feldman M, Shenderovich J, Lavy E, Friedman M, Steinberg D. A Sustained-Release Membrane of Thiazolidinedione-8: Effect on Formation of a Candida/Bacteria Mixed Biofilm on Hydroxyapatite in a Continuous Flow Model. Biomed Res Int. 2017;2017:3510124. doi: 10.1155/2017/3510124. Epub 2017 Oct 10. PubMed PMID: 29130039; PubMed Central PMCID: PMC5654278. 2: Feldman M, Ginsburg I, Al-Quntar A, Steinberg D. Thiazolidinedione-8 Alters Symbiotic Relationship in C. albicans-S. mutans Dual Species Biofilm. Front Microbiol. 2016 Feb 10;7:140. doi: 10.3389/fmicb.2016.00140. eCollection 2016. PubMed PMID: 26904013; PubMed Central PMCID: PMC4748032. 3: Shenderovich J, Feldman M, Kirmayer D, Al-Quntar A, Steinberg D, Lavy E, Friedman M. Local sustained-release delivery systems of the antibiofilm agent thiazolidinedione-8 for prevention of catheter-associated urinary tract infections. Int J Pharm. 2015 May 15;485(1-2):164-70. doi: 10.1016/j.ijpharm.2015.02.067. Epub 2015 Mar 10. PubMed PMID: 25769292. 4: Feldman M, Shenderovich J, Al-Quntar AA, Friedman M, Steinberg D. Sustained release of a novel anti-quorum-sensing agent against oral fungal biofilms. Antimicrob Agents Chemother. 2015 Apr;59(4):2265-72. doi: 10.1128/AAC.04212-14. Epub 2015 Feb 2. PubMed PMID: 25645835; PubMed Central PMCID: PMC4356767. 5: Feldman M, Al-Quntar A, Polacheck I, Friedman M, Steinberg D. Therapeutic potential of thiazolidinedione-8 as an antibiofilm agent against Candida albicans. PLoS One. 2014 May 5;9(5):e93225. doi: 10.1371/journal.pone.0093225. eCollection 2014. PubMed PMID: 24796422; PubMed Central PMCID: PMC4010395.