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MedKoo Cat#: 584545 | Name: Jedi2
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Jedi2 is a Piezo1 channel activator that promotes Ca2+ influx into HEK293 cells expressing Piezo1 channels and elicits responses in mouse Piezo1-transfected, but not Piezo2-transfected cells.

Chemical Structure

Jedi2
Jedi2
CAS#651005-90-2

Theoretical Analysis

MedKoo Cat#: 584545

Name: Jedi2

CAS#: 651005-90-2

Chemical Formula: C10H8O3S

Exact Mass: 208.0194

Molecular Weight: 208.23

Elemental Analysis: C, 57.68; H, 3.87; O, 23.05; S, 15.40

Price and Availability

Size Price Availability Quantity
5mg USD 295.00 2 Weeks
10mg USD 450.00 2 Weeks
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Related CAS #
No Data
Synonym
Jedi2
IUPAC/Chemical Name
2-Methyl-5-(2-thienyl)-3-furancarboxylic acid
InChi Key
YXDCRSXNEOKXDE-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H8O3S/c1-6-7(10(11)12)5-8(13-6)9-3-2-4-14-9/h2-5H,1H3,(H,11,12)
SMILES Code
O=C(C1=C(C)OC(C2=CC=CS2)=C1)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Jedi2 is a Piezo1 activator, but not a specific Piezo2 activator. Jedi2 binds to the mouse Piezo1 proteins with a Kd of 2770  μM.
In vitro activity:
TBD
In vivo activity:
TBD
Solvent mg/mL mM
Solubility
DMSO 35.4 170.05
Ethanol 20.8 99.99
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 208.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
Wang et al (2018) A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel. Nat.Commun. 9 1300 PMID: 29610524