MedKoo Cat#: 563837 | Name: SRI-29574
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

SRI-29574 is an allosteric dopamine transporter ligand.

Chemical Structure

SRI-29574
CAS#1928712-46-2

Theoretical Analysis

MedKoo Cat#: 563837

Name: SRI-29574

CAS#: 1928712-46-2

Chemical Formula: C29H23N5

Exact Mass: 441.1953

Molecular Weight: 441.54

Elemental Analysis: C, 78.89; H, 5.25; N, 15.86

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Related CAS #
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Synonym
SRI-29574; SRI-29574; SRI-29574
IUPAC/Chemical Name
N-(2,2-Diphenylethyl)-2-(imidazo[1,2-a]pyridin-6-yl)quinazolin-4-amine
InChi Key
CLQYCNGZRPKVQF-UHFFFAOYSA-N
InChi Code
InChI=1S/C29H23N5/c1-3-9-21(10-4-1)25(22-11-5-2-6-12-22)19-31-29-24-13-7-8-14-26(24)32-28(33-29)23-15-16-27-30-17-18-34(27)20-23/h1-18,20,25H,19H2,(H,31,32,33)
SMILES Code
C1(C2=CN3C(C=C2)=NC=C3)=NC(NCC(C4=CC=CC=C4)C5=CC=CC=C5)=C6C=CC=CC6=N1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
SRI-29574 can partially inhibit DAT uptake, with an IC50 = 2.3 ± 0.4 nM, without affecting binding to the DAT.

Preparing Stock Solutions

The following data is based on the product molecular weight 441.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Rothman RB, Ananthan S, Partilla JS, Saini SK, Moukha-Chafiq O, Pathak V, Baumann MH. Studies of the biogenic amine transporters 15. Identification of novel allosteric dopamine transporter ligands with nanomolar potency. J Pharmacol Exp Ther. 2015 Jun;353(3):529-38. doi: 10.1124/jpet.114.222299. Epub 2015 Mar 18. PMID: 25788711; PMCID: PMC4429677.