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MedKoo Cat#: 563830 | Name: Photoregulin3
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Photoregulin3 is a inhibitor of rod photoreceptor gene expression, potentially though Nr2e3 modulation.

Chemical Structure

Photoregulin3
Photoregulin3
CAS#785708-33-0

Theoretical Analysis

MedKoo Cat#: 563830

Name: Photoregulin3

CAS#: 785708-33-0

Chemical Formula: C22H23N3O3

Exact Mass: 377.1739

Molecular Weight: 377.44

Elemental Analysis: C, 70.01; H, 6.14; N, 11.13; O, 12.72

Price and Availability

Size Price Availability Quantity
5mg USD 295.00
25mg USD 750.00
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Related CAS #
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Synonym
Photoregulin3; Photoregulin 3; Photoregulin-3; PR3; PR 3; PR-3
IUPAC/Chemical Name
6,7-Dimethoxy-2-((4-phenyl-3,6-dihydropyridin-1(2H)-yl)methyl)quinazolin-4-ol
InChi Key
CKCSOMMBIPJYSG-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H23N3O3/c1-27-19-12-17-18(13-20(19)28-2)23-21(24-22(17)26)14-25-10-8-16(9-11-25)15-6-4-3-5-7-15/h3-8,12-13H,9-11,14H2,1-2H3,(H,23,24,26)
SMILES Code
OC1=C2C=C(OC)C(OC)=CC2=NC(CN3CC=C(C4=CC=CC=C4)CC3)=N1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
T4 is a modulator of alternative polyadenylation (APA) (IC50 values are 2.1 μM and 8.5 μM in U2OS and 293T cells, respectively).
In vitro activity:
TBD
In vivo activity:
This study reports a structurally unrelated compound, Photoregulin3 (PR3) that also inhibits rod photoreceptor gene expression, potentially though Nr2e3 modulation. To determine the effectiveness of PR3 as a potential therapy for RP, this study treated RhoP23H mice with PR3 and assessed retinal structure and function. PR3-treated RhoP23H mice showed significant structural and functional photoreceptor rescue compared with vehicle-treated littermate control mice. Reference: Elife. 2017 Nov 17;6:e30577. https://pubmed.ncbi.nlm.nih.gov/29148976/
Solvent mg/mL mM comments
Solubility
DMSO 0.8 2.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 377.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
Nakamura PA, Shimchuk AA, Tang S, Wang Z, DeGolier K, Ding S, Reh TA. Small molecule Photoregulin3 prevents retinal degeneration in the RhoP23H mouse model of retinitis pigmentosa. Elife. 2017 Nov 17;6:e30577. doi: 10.7554/eLife.30577. PMID: 29148976; PMCID: PMC5693111.
In vitro protocol:
TBD
In vivo protocol:
Nakamura PA, Shimchuk AA, Tang S, Wang Z, DeGolier K, Ding S, Reh TA. Small molecule Photoregulin3 prevents retinal degeneration in the RhoP23H mouse model of retinitis pigmentosa. Elife. 2017 Nov 17;6:e30577. doi: 10.7554/eLife.30577. PMID: 29148976; PMCID: PMC5693111.
1: Nakamura PA, Shimchuk AA, Tang S, Wang Z, DeGolier K, Ding S, Reh TA. Small molecule Photoregulin3 prevents retinal degeneration in the RhoP23H mouse model of retinitis pigmentosa. Elife. 2017 Nov 17;6. pii: e30577. doi: 10.7554/eLife.30577. PubMed PMID: 29148976; PubMed Central PMCID: PMC5693111. Kandoi S, Martinez C, Chen KX, Mehine M, Reddy LVK, Mansfield BC, Duncan JL, Lamba DA. Disease modeling and pharmacological rescue of autosomal dominant retinitis pigmentosa associated with RHO copy number variation. Elife. 2024 Apr 25;12:RP90575. doi: 10.7554/eLife.90575. PMID: 38661530; PMCID: PMC11045220.