MedKoo Cat#: 555313 | Name: PSB-18484

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PSB-18484 is a Potent Agonists of the Orphan G Protein-Coupled Receptor GPR17 (EC50 = 32.1 nM).

Chemical Structure

PSB-18484
PSB-18484
CAS#Unknown

Theoretical Analysis

MedKoo Cat#: 555313

Name: PSB-18484

CAS#: Unknown

Chemical Formula: C12H9FINO4

Exact Mass: 376.9560

Molecular Weight: 377.11

Elemental Analysis: C, 38.22; H, 2.41; F, 5.04; I, 33.65; N, 3.71; O, 16.97

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
PSB-18484; PSB 18484; PSB18484.
IUPAC/Chemical Name
3-(2-Carboxyethyl)-4-fluoro-6-iodo-1H-indole-2-carboxylic Acid
InChi Key
DDCPVTXQTABQGM-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H9FINO4/c13-7-3-5(14)4-8-10(7)6(1-2-9(16)17)11(15-8)12(18)19/h3-4,15H,1-2H2,(H,16,17)(H,18,19)
SMILES Code
O=C(C(N1)=C(CCC(O)=O)C2=C1C=C(I)C=C2F)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
The orphan receptor GPR17 may be a novel drug target for inflammatory diseases. GPR17 antagonists have potential for the treatment of demyelinating diseases such as multiple sclerosis based on the observation that GPR17 knockout mice showed increased myelination.

Preparing Stock Solutions

The following data is based on the product molecular weight 377.11 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Baqi Y, Pillaiyar T, Abdelrahman A, Kaufmann O, Alshaibani S, Rafehi M, Ghasimi S, Akkari R, Ritter K, Simon K, Spinrath A, Kostenis E, Zhao Q, Köse M, Namasivayam V, Müller CE. 3-(2-Carboxyethyl)indole-2-carboxylic Acid Derivatives: Structural Requirements and Properties of Potent Agonists of the Orphan G Protein-Coupled Receptor GPR17. J Med Chem. 2018 Sep 5. doi: 10.1021/acs.jmedchem.7b01768. [Epub ahead of print] PubMed PMID: 30048589.