SPDP acid | CAS# 68617-64-1 | non-PEG Linker

MedKoo Cat#: 572665 | Name: SPDP acid

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

SPDP acid is a non-PEG crosslinker.

Chemical Structure

SPDP acid

CAS#68617-64-1

Theoretical Analysis

MedKoo Cat#: 572665

Name: SPDP acid

CAS#: 68617-64-1

Chemical Formula: C8H9NO2S2

Exact Mass: 215.0075

Molecular Weight: 215.28

Elemental Analysis: C, 44.63; H, 4.21; N, 6.51; O, 14.86; S, 29.78

Price and Availability

Size	Price	Availability
250mg	USD 550.00	2 weeks
500mg	USD 1,000.00	2 weeks
1g	USD 1,500.00	2 weeks

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Related CAS #

No Data

Synonym

SPDP acid

IUPAC/Chemical Name

3-(pyridin-2-yldisulfanyl)propanoic acid

InChi Key

DJBRKGZFUXKLKO-UHFFFAOYSA-N

InChi Code

InChI=1S/C8H9NO2S2/c10-8(11)4-6-12-13-7-3-1-2-5-9-7/h1-3,5H,4,6H2,(H,10,11)

SMILES Code

OC(CCSSC1=NC=CC=C1)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

SPDP acid can be used in the synthesis of PROTACs.

In vitro activity:

To be determined

In vivo activity:

To be determined

	Solvent	mg/mL	mM	comments
Solubility
	DMSO	250.0	1,161.22

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 215.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

To be determined

In vitro protocol:

To be determined

In vivo protocol:

To be determined

1: Boni FI, Prezotti FG, Cury BS. Gellan gum microspheres crosslinked with trivalent ion: effect of polymer and crosslinker concentrations on drug release and mucoadhesive properties. Drug Dev Ind Pharm. 2016 Aug;42(8):1283-90. doi: 10.3109/03639045.2015.1125915. Epub 2016 Jan 29. PubMed PMID: 26616390. 2: Van Haute D, Longmate JM, Berlin JM. Controlled Assembly of Biocompatible Metallic Nanoaggregates Using a Small Molecule Crosslinker. Adv Mater. 2015 Sep 16;27(35):5158-64. doi: 10.1002/adma.201501602. Epub 2015 Jul 24. PubMed PMID: 26208123; PubMed Central PMCID: PMC4567412. 3: Rao Z, Sasaki M, Taguchi T. Development of amphiphilic, enzymatically-degradable PEG-peptide conjugate as cell crosslinker for spheroid formation. Colloids Surf B Biointerfaces. 2013 Jan 1;101:223-7. doi: 10.1016/j.colsurfb.2012.06.033. Epub 2012 Jul 4. PubMed PMID: 23010023.