ICT2700 | duocarmycin analogue

MedKoo Cat#: 563804 | Name: ICT2700

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ICT2700 is a potent cytotoxin selectively by CYP1A1 as a tumor-selective treatment for human bladder cancers.

Chemical Structure

ICT2700

CAS#NONE

Theoretical Analysis

MedKoo Cat#: 563804

Name: ICT2700

CAS#: NONE

Chemical Formula: C21H18ClN3O2

Exact Mass: 379.1088

Molecular Weight: 379.84

Elemental Analysis: C, 66.40; H, 4.78; Cl, 9.33; N, 11.06; O, 8.42

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

ICT2700; ICT 2700; ICT-2700; de-OH-CPI-MI; deOHCPIMI; de OH CPI MI

IUPAC/Chemical Name

(1-Chloromethyl-1,6-dihydro-2H-3,6-diaza-as-indacen-3-yl)-(6-methoxy-1H-indol-2-yl)-methanone

InChi Key

XRNCIYOOVQKJAV-UHFFFAOYSA-N

InChi Code

InChI=1S/C21H18ClN3O2/c1-27-14-3-2-12-8-18(24-17(12)9-14)21(26)25-11-13(10-22)20-15-6-7-23-16(15)4-5-19(20)25/h2-9,13,23-24H,10-11H2,1H3

SMILES Code

O=C(N1CC(CCl)C2=C1C=CC3=C2C=CN3)C(N4)=CC5=C4C=C(OC)C=C5

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 379.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Sutherland M, Gill JH, Loadman PM, Laye JP, Sheldrake HM, Illingworth NA, Alandas MN, Cooper PA, Searcey M, Pors K, Shnyder SD, Patterson LH. Antitumor activity of a duocarmycin analogue rationalized to be metabolically activated by cytochrome P450 1A1 in human transitional cell carcinoma of the bladder. Mol Cancer Ther. 2013 Jan;12(1):27-37. doi: 10.1158/1535-7163.MCT-12-0405. Epub 2012 Oct 1. PubMed PMID: 23033491. 2: Pors K, Loadman PM, Shnyder SD, Sutherland M, Sheldrake HM, Guino M, Kiakos K, Hartley JA, Searcey M, Patterson LH. Modification of the duocarmycin pharmacophore enables CYP1A1 targeting for biological activity. Chem Commun (Camb). 2011 Nov 28;47(44):12062-4. doi: 10.1039/c1cc15638a. Epub 2011 Oct 14. PubMed PMID: 22002321.