MedKoo Cat#: 563770 | Name: Dihydroresveratrol
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dihydroresveratrol is an SIRT1 activator. It is a primary metabolite of resveratrol.

Chemical Structure

Dihydroresveratrol
CAS#58436-28-5

Theoretical Analysis

MedKoo Cat#: 563770

Name: Dihydroresveratrol

CAS#: 58436-28-5

Chemical Formula: C14H14O3

Exact Mass: 230.0943

Molecular Weight: 230.26

Elemental Analysis: C, 73.03; H, 6.13; O, 20.84

Price and Availability

Size Price Availability Quantity
100mg USD 450.00 2 Weeks
250mg USD 850.00 2 Weeks
1g USD 1,650.00 2 Weeks
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Synonym
Dihydroresveratrol; Di-hydroresveratrol; Di hydroresveratrol; DHRSV
IUPAC/Chemical Name
5-[2-(4-Hydroxyphenyl)ethyl]benzene-1,3-diol
InChi Key
HITJFUSPLYBJPE-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H14O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h3-9,15-17H,1-2H2
SMILES Code
OC1=CC(CCC2=CC=C(O)C=C2)=CC(O)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Biological target:
Dihydroresveratrol, a potent phytoestrogen, is a hormone receptor modulator.
In vitro activity:
Dihydro-R (dihydroresveratrol) exhibits proliferative effects in androgen-independent prostate cancer cells at picomolar and nanomolar concentrations. Reference: Chem Cent J. 2011 Dec 20;5:88. https://pubmed.ncbi.nlm.nih.gov/22185600/
In vivo activity:
When treated with dihydro-resveratrol, pulmonary architectural distortion, hemorrhage, interstitial edema, and alveolar thickening were significantly reduced in rats with acute pancreatitis. In addition, the production of pro-inflammatory cytokines and the activity of myeloperoxidase in pulmonary tissues were notably repressed. Reference: Phytother Res. 2016 Apr;30(4):663-70. https://pubmed.ncbi.nlm.nih.gov/26833708/
Solvent mg/mL mM comments
Solubility
DMSO 73.0 317.03
Ethanol 46.0 199.77
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 230.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Anisimova NY, Kiselevsky MV, Sosnov AV, Sadovnikov SV, Stankov IN, Gakh AA. Trans-, cis-, and dihydro-resveratrol: a comparative study. Chem Cent J. 2011 Dec 20;5:88. doi: 10.1186/1752-153X-5-88. PMID: 22185600; PMCID: PMC3313904. 2. Gakh AA, Anisimova NY, Kiselevsky MV, Sadovnikov SV, Stankov IN, Yudin MV, Rufanov KA, Krasavin MY, Sosnov AV. Dihydro-resveratrol--a potent dietary polyphenol. Bioorg Med Chem Lett. 2010 Oct 15;20(20):6149-51. doi: 10.1016/j.bmcl.2010.08.002. Epub 2010 Aug 5. PMID: 20813524. 3. Lin ZS, Ku CF, Guan YF, Xiao HT, Shi XK, Wang HQ, Bian ZX, Tsang SW, Zhang HJ. Dihydro-Resveratrol Ameliorates Lung Injury in Rats with Cerulein-Induced Acute Pancreatitis. Phytother Res. 2016 Apr;30(4):663-70. doi: 10.1002/ptr.5576. Epub 2016 Feb 1. PMID: 26833708.
In vitro protocol:
1. Anisimova NY, Kiselevsky MV, Sosnov AV, Sadovnikov SV, Stankov IN, Gakh AA. Trans-, cis-, and dihydro-resveratrol: a comparative study. Chem Cent J. 2011 Dec 20;5:88. doi: 10.1186/1752-153X-5-88. PMID: 22185600; PMCID: PMC3313904. 2. Gakh AA, Anisimova NY, Kiselevsky MV, Sadovnikov SV, Stankov IN, Yudin MV, Rufanov KA, Krasavin MY, Sosnov AV. Dihydro-resveratrol--a potent dietary polyphenol. Bioorg Med Chem Lett. 2010 Oct 15;20(20):6149-51. doi: 10.1016/j.bmcl.2010.08.002. Epub 2010 Aug 5. PMID: 20813524.
In vivo protocol:
1. Lin ZS, Ku CF, Guan YF, Xiao HT, Shi XK, Wang HQ, Bian ZX, Tsang SW, Zhang HJ. Dihydro-Resveratrol Ameliorates Lung Injury in Rats with Cerulein-Induced Acute Pancreatitis. Phytother Res. 2016 Apr;30(4):663-70. doi: 10.1002/ptr.5576. Epub 2016 Feb 1. PMID: 26833708.
1: Oode C, Shimada W, Izutsu Y, Yokota M, Iwadate T, Nihei K. Synthesis of dihydroresveratrol glycosides and evaluation of their activity against melanogenesis in B16F0 melanoma cells. Eur J Med Chem. 2014 Nov 24;87:862-7. doi: 10.1016/j.ejmech.2014.09.092. Epub 2014 Oct 2. PubMed PMID: 25440886. 2: Radko Y, Christensen KB, Christensen LP. Semi-preparative isolation of dihydroresveratrol-3-O-β-d-glucuronide and four resveratrol conjugates from human urine after oral intake of a resveratrol-containing dietary supplement. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Jul 1;930:54-61. doi: 10.1016/j.jchromb.2013.05.002. Epub 2013 May 7. PubMed PMID: 23727867. 3: Faragher RG, Burton DG, Majecha P, Fong NS, Davis T, Sheerin A, Ostler EL. Resveratrol, but not dihydroresveratrol, induces premature senescence in primary human fibroblasts. Age (Dordr). 2011 Dec;33(4):555-64. doi: 10.1007/s11357-010-9201-5. Epub 2011 Feb 12. PubMed PMID: 21318333; PubMed Central PMCID: PMC3220406. 4: Oode C, Shimada W, Yokota M, Yamada Y, Nihei KI. Dihydroresveratrol cellobioside and xylobioside as effective melanogenesis activators. Carbohydr Res. 2016 Dec 21;436:45-49. doi: 10.1016/j.carres.2016.11.004. Epub 2016 Nov 9. PubMed PMID: 27863303. 5: Juan ME, Alfaras I, Planas JM. Determination of dihydroresveratrol in rat plasma by HPLC. J Agric Food Chem. 2010 Jun 23;58(12):7472-5. doi: 10.1021/jf100836j. PubMed PMID: 20509689. 6: Xie CF, Yuan HQ, Qu JB, Xing J, Lü BB, Wang XN, Ji M, Lou HX. Biocatalytic production of acyclic bis[bibenzyls] from dihydroresveratrol by crude Momordica charantia peroxidase. Chem Biodivers. 2009 Aug;6(8):1193-201. doi: 10.1002/cbdv.200800229. PubMed PMID: 19697337. 7: Lin ZS, Ku CF, Guan YF, Xiao HT, Shi XK, Wang HQ, Bian ZX, Tsang SW, Zhang HJ. Dihydro-Resveratrol Ameliorates Lung Injury in Rats with Cerulein-Induced Acute Pancreatitis. Phytother Res. 2016 Apr;30(4):663-70. doi: 10.1002/ptr.5576. Epub 2016 Feb 1. PubMed PMID: 26833708. 8: Tsang SW, Guan YF, Wang J, Bian ZX, Zhang HJ. Inhibition of pancreatic oxidative damage by stilbene derivative dihydro-resveratrol: implication for treatment of acute pancreatitis. Sci Rep. 2016 Mar 14;6:22859. doi: 10.1038/srep22859. PubMed PMID: 26971398; PubMed Central PMCID: PMC4789643. 9: Anisimova NY, Kiselevsky MV, Sosnov AV, Sadovnikov SV, Stankov IN, Gakh AA. Trans-, cis-, and dihydro-resveratrol: a comparative study. Chem Cent J. 2011 Dec 20;5:88. doi: 10.1186/1752-153X-5-88. PubMed PMID: 22185600; PubMed Central PMCID: PMC3313904. 10: Vitalini S, Cicek SS, Granica S, Zidorn C. Dihydroresveratrol Type Dihydrostilbenoids: Chemical Diversity, Chemosystematics, and Bioactivity. Curr Med Chem. 2018;25(10):1194-1240. doi: 10.2174/0929867324666170830112343. PubMed PMID: 28875843.