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MedKoo Cat#: 563760 | Name: Acetylbritannilactone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Acetylbritannilactone is a Natural inhibitor of HSP60 chaperone activity through covalent binding.

Chemical Structure

Acetylbritannilactone
Acetylbritannilactone
CAS#744203-09-6

Theoretical Analysis

MedKoo Cat#: 563760

Name: Acetylbritannilactone

CAS#: 744203-09-6

Chemical Formula: C17H24O5

Exact Mass: 308.1600

Molecular Weight: 308.37

Elemental Analysis: C, 66.21; H, 7.85; O, 25.94

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Acetylbritannilactone; 1-O-Acetylbritannilactone; 1-o-Acetylbritannilactone
IUPAC/Chemical Name
1-O-Acetylbritannilactone; [(4S)-4-[(3aS,4S,7aR)-4-hydroxy-6-methyl-3-methylidene-2-oxo-3a,4,7,7a-tetrahydro-1-benzofuran-5-yl]pentyl] acetate
InChi Key
QKUFZFLZBUSEHN-CZLJMHDISA-N
InChi Code
InChI=1S/C17H24O5/c1-9(6-5-7-21-12(4)18)14-10(2)8-13-15(16(14)19)11(3)17(20)22-13/h9,13,15-16,19H,3,5-8H2,1-2,4H3/t9-,13+,15+,16+/m0/s1
SMILES Code
CC(OCCC[C@@H](C1=C(C)C[C@](OC2=O)([H])[C@@]([C@@H]1O)([H])C2=C)C)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 308.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhengfu H, Hu Z, Huiwen M, Zhijun L, Jiaojie Z, Xiaoyi Y, Xiujun C. 1-o-acetylbritannilactone (ABL) inhibits angiogenesis and lung cancer cell growth through regulating VEGF-Src-FAK signaling. Biochem Biophys Res Commun. 2015 Aug 21;464(2):422-7. doi: 10.1016/j.bbrc.2015.06.126. Epub 2015 Jun 20. PubMed PMID: 26102035. 2: Wen Y, Zhang X, Dong L, Zhao J, Zhang C, Zhu C. Acetylbritannilactone Modulates MicroRNA-155-Mediated Inflammatory Response in Ischemic Cerebral Tissues. Mol Med. 2015 Mar 18;21:197-209. doi: 10.2119/molmed.2014.00199. PubMed PMID: 25811992; PubMed Central PMCID: PMC4503649. 3: Liu S, Feng J, Liu H, Li J, Tian X. Design, synthesis, and antitumor activity of novel acylate of 6-OH at 1- O-acetylbritannilactone. Med Chem. 2015;11(2):200-5. PubMed PMID: 25134429. 4: Liu B, Wen JK, Li BH, Fang XM, Wang JJ, Zhang YP, Shi CJ, Zhang DQ, Han M. Celecoxib and acetylbritannilactone interact synergistically to suppress breast cancer cell growth via COX-2-dependent and -independent mechanisms. Cell Death Dis. 2011 Jul 28;2:e185. doi: 10.1038/cddis.2011.64. Erratum in: Cell Death Dis. 2011;2:e206. PubMed PMID: 21796157; PubMed Central PMCID: PMC3199716.