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MedKoo Cat#: 563756 | Name: BRAF-423

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BRAF-423, also known as G-F, is a novel potent and selective BRAF inhibitor. BRAF-423 has no formal name, has molecule weight 423. For the convenience of scientific communication, We temporally call it as BRAF-423.

Chemical Structure

BRAF-423
BRAF-423
CAS#NONE

Theoretical Analysis

MedKoo Cat#: 563756

Name: BRAF-423

CAS#: NONE

Chemical Formula: C19H19F2N3O4S

Exact Mass: 423.1064

Molecular Weight: 423.43

Elemental Analysis: C, 53.89; H, 4.52; F, 8.97; N, 9.92; O, 15.11; S, 7.57

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
G-F; BRAF-423; BRAF 423; BRAF423.
IUPAC/Chemical Name
2,6-Difluoro-N-(3-methoxy-1H-indol-5-yl)-3-(propylsulfonamido)benzamide
InChi Key
ZWAGSOCCDPGKEI-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H19F2N3O4S/c1-3-8-29(26,27)24-15-7-5-13(20)17(18(15)21)19(25)23-11-4-6-14-12(9-11)16(28-2)10-22-14/h4-7,9-10,22,24H,3,8H2,1-2H3,(H,23,25)
SMILES Code
O=C(NC1=CC2=C(NC=C2OC)C=C1)C3=C(F)C=CC(NS(=O)(CCC)=O)=C3F
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 423.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sahoo A, Sahoo SK, Joshi P, Lee B, Perera RJ. MicroRNA-211 loss promotes metabolic vulnerability and BRAF inhibitor sensitivity in melanoma. J Invest Dermatol. 2018 Aug 1. pii: S0022-202X(18)32458-8. doi: 10.1016/j.jid.2018.06.189. [Epub ahead of print] PubMed PMID: 30076926. 2: Gavric AU, Ocvirk J, Mekjavic PJ. Ocular Changes in Metastatic Melanoma Patients Treated with MEK Inhibitor Cobimetinib and BRAF Inhibitor Vemurafenib. Radiol Oncol. 2018 Jan 24;52(2):213-219. doi: 10.2478/raon-2018-0002. eCollection 2018 Jun. PubMed PMID: 30018526; PubMed Central PMCID: PMC6043881. 3: Wang X, Qu H, Dong Y, Wang G, Zhen Y, Yi P. Targeting signal-transducer-and-activator-of-transcription 3 sensitizes human cutaneous melanoma cells to BRAF inhibitor. Cancer Biomark. 2018 Jun 28. doi: 10.3233/CBM-181365. [Epub ahead of print] PubMed PMID: 30010109. 4: Mooradian MJ, Reuben A, Prieto PA, Hazar-Rethinam M, Frederick DT, Nadres B, Piris A, Juneja V, Cooper ZA, Sharpe AH, Corcoran RB, Flaherty KT, Lawrence DP, Wargo JA, Sullivan RJ. A phase II study of combined therapy with a BRAF inhibitor (vemurafenib) and interleukin-2 (aldesleukin) in patients with metastatic melanoma. Oncoimmunology. 2018 Feb 1;7(5):e1423172. doi: 10.1080/2162402X.2017.1423172. eCollection 2018. PubMed PMID: 29721378; PubMed Central PMCID: PMC5927481.