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MedKoo Cat#: 593128 | Name: Actodigin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Actodiginis a Cardiotonic drug.

Chemical Structure

Actodigin
Actodigin
CAS#36983-69-4

Theoretical Analysis

MedKoo Cat#: 593128

Name: Actodigin

CAS#: 36983-69-4

Chemical Formula: C29H44O9

Exact Mass: 536.2985

Molecular Weight: 536.66

Elemental Analysis: C, 64.90; H, 8.26; O, 26.83

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
NSC 53396; NSC-53396; NSC53396; Actodigin
IUPAC/Chemical Name
24-Nor-5,14-chol-20(22)-en-21-oic acid, 3-(beta-D-glucopyranosyloxy)-14,23-dihydroxy-, gamma-lactone, (3beta,5beta,14beta)-
InChi Key
ACLJAFRNPZVVIW-ADFGDECNSA-N
InChi Code
InChI=1S/C29H44O9/c1-27-9-5-16(37-26-24(33)23(32)22(31)21(14-30)38-26)13-15(27)3-4-20-19(27)6-10-28(2)18(7-11-29(20,28)35)17-8-12-36-25(17)34/h8,15-16,18-24,26,30-33,35H,3-7,9-14H2,1-2H3/t15-,16+,18-,19+,20-,21-,22-,23+,24-,26-,27+,28-,29+/m1/s1
SMILES Code
C[C@]12CC[C@@H](C[C@H]1CC[C@@H]3[C@@H]2CC[C@]4(C)[C@H](CC[C@]34O)C5=CCOC5=O)O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 536.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ruch SR, Nishio M, Wasserstrom JA. Effect of cardiac glycosides on action potential characteristics and contractility in cat ventricular myocytes: role of calcium overload. J Pharmacol Exp Ther. 2003 Oct;307(1):419-28. Epub 2003 Sep 3. PubMed PMID: 12954807. 2: Sagawa T, Sagawa K, Kelly JE, Tsushima RG, Wasserstrom JA. Activation of cardiac ryanodine receptors by cardiac glycosides. Am J Physiol Heart Circ Physiol. 2002 Mar;282(3):H1118-26. PubMed PMID: 11834511. 3: Wasserstrom JA. Changes in intracellular Na+ during Na,K pump inhibition in sheep cardiac tissues. J Mol Cell Cardiol. 1992 Jan;24(1):1-7. PubMed PMID: 1314312. 4: Wasserstrom JA, Farkas DE, Norell MA, Vereault DV. Effects of different cardiac steroids on intracellular sodium, inotropy and toxicity in sheep Purkinje fibers. J Pharmacol Exp Ther. 1991 Sep;258(3):918-25. PubMed PMID: 1890626. 5: Wasserstrom JA, Farkas DE. Inotropic and toxic actions of several cardiac steroids in sheep cardiac tissues. Prog Clin Biol Res. 1988;268B:469-76. PubMed PMID: 3222261. 6: Gupta RS, Chopra A. Human cell mutants affected in the interaction of the 12 beta-OH group of cardiac glycosides with the digitalis receptor. Biochem Pharmacol. 1987 Nov 15;36(22):3829-33. PubMed PMID: 2825704. 7: Gupta RS, Chopra A, Stetsko DK. Cellular basis for the species differences in sensitivity to cardiac glycosides (digitalis). J Cell Physiol. 1986 May;127(2):197-206. PubMed PMID: 3009493. 8: Gupta RS, Chopra A. Cross-resistance and biochemical studies with two classes of HeLa cell mutants resistant to cardiac glycosides. The unusual behavior of cardenolide SC4453. J Biol Chem. 1985 Jun 10;260(11):6843-50. PubMed PMID: 2987235. 9: Haustein KO. Therapeutic range of cardiac glycosides. Basic Res Cardiol. 1984;79 Suppl:147-53. PubMed PMID: 6331374. 10: Wasserstrom JA, Schwartz DJ, Fozzard HA. Relation between intracellular sodium and twitch tension in sheep cardiac Purkinje strands exposed to cardiac glycosides. Circ Res. 1983 Jun;52(6):697-705. PubMed PMID: 6305531. 11: Pastelín G, Mendez R. Cardiac effects of six actodigin (AY-22,241)-related semisynthetic glycosides. Life Sci. 1983 Apr 18;32(16):1905-9. PubMed PMID: 6835014. 12: Méndez R. [The old digitalis and the new cardiac inotropic agents]. Arch Farmacol Toxicol. 1983 Apr;9(1):4-20. Review. Spanish. PubMed PMID: 6354106. 13: Charnock JS, Dryden WF, Marshall RJ. Seasonal variations in drug response and staircase phenomena in atrial muscle from a hibernating rodent (Spermophilus richardsonii). Br J Pharmacol. 1983 Jan;78(1):151-8. PubMed PMID: 6297645; PubMed Central PMCID: PMC2044769. 14: Wasserstrom JA, Ferrier GR. Effects of phenytoin and quinidine on digitalis-induced oscillatory afterpotentials, aftercontractions, and inotropy in canine ventricular tissues. J Mol Cell Cardiol. 1982 Dec;14(12):725-36. PubMed PMID: 7166762. 15: Wasserstrom JA, Ferrier GR. Voltage dependence of digitalis afterpotentials, aftercontractions, and inotropy. Am J Physiol. 1981 Oct;241(4):H646-53. PubMed PMID: 7315990. 16: Fullerton DS, Yoshioka K, Rohrer DC, From AH, Ahmed K. A crystallographic, conformational energy, and biological study of Actodigin (AY-22,241) and its genin. Mol Pharmacol. 1980 Jan;17(1):43-51. PubMed PMID: 6247637. 17: Charnock JS, Dryden WF, Marshall RJ, Lauzon P. Dissociation of inotropic and toxic effects of the semisynthetic cardiac glycoside actodigin during hibernation in the ground-squirrel. Comp Biochem Physiol C. 1980;67C(1):1-7. PubMed PMID: 6107205. 18: Charnock JS, Dryden WF, Lauzon PA. Species difference in myocardial response to actodigin: correlation with inhibition of myocardial (Na+ + K+)-ATPase. Comp Biochem Physiol C. 1980;66(2):153-8. PubMed PMID: 6107199. 19: Deitmer JW, Ellis D. The intracellular sodium activity of cardiac Purkinje fibres during inhibition and re-activation of the Na-K pump. J Physiol. 1978 Nov;284:241-59. PubMed PMID: 731536; PubMed Central PMCID: PMC1282820. 20: Cagin NA, Naidu S, Arvan S, Goldman I, Somberg J, Levitt B. Effects of actodigin on the heart. Clin Pharmacol Ther. 1977 Sep;22(3):274-9. PubMed PMID: 891095.