MedKoo Cat#: 593115 | Name: Methallibure

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Methallibure is a dithiobiurea compound with anti-gonadotropic activity.

Chemical Structure

Methallibure
Methallibure
CAS#926-93-2

Theoretical Analysis

MedKoo Cat#: 593115

Name: Methallibure

CAS#: 926-93-2

Chemical Formula: C7H14N4S2

Exact Mass: 218.0660

Molecular Weight: 218.34

Elemental Analysis: C, 38.51; H, 6.46; N, 25.66; S, 29.37

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Methallibure
IUPAC/Chemical Name
1,2-Hydrazinedicarbothioamide, N-methyl-N'-(1-methyl-2-propenyl)-
InChi Key
CGFFKDRVHZIQHL-UHFFFAOYSA-N
InChi Code
InChI=1S/C7H14N4S2/c1-4-5(2)9-7(13)11-10-6(12)8-3/h4-5H,1H2,2-3H3,(H2,8,10,12)(H2,9,11,13)
SMILES Code
S=C(NNC(NC(C)C=C)=S)NC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 218.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Joy KP, Singh MS, Senthilkumaran B, Goos HJ. Pituitary-gonadal Relationship in the Catfish Clarias batrachus (L): A Study Correlating Gonadotrophin-II and Sex Steroid Dynamics. Zoolog Sci. 2000 Apr 1;17(3):395-404. doi: 10.2108/jsz.17.395. PubMed PMID: 18494596. 2: Singh MS, Joy KP. Methallibure inhibition of testicular and seminal vesicle activity in catfish, Clarias batrachus (Linn.): a study correlating changes in serum sex steroid profiles. Acta Biol Hung. 2000;51(1):45-53. PubMed PMID: 10866360. 3: Stickan F, Parvizi N, Elsaesser F. Compensation by pulsatile GnRH infusions for incompetence for oestradiol-induced LH surges in long-term ovariectomized gilts and castrated male pigs. J Reprod Fertil. 1999 Mar;115(2):333-9. PubMed PMID: 10434939. 4: Chang WJ, Barb CR, Kraeling RR, Rampacek GB, Wright JT. Biogenic amines in the hypothalamus of rats after diethyldithiocarbamate or AIMAX treatment, an alternative for norepinephrine depletion. J Anim Sci. 1995 Apr;73(4):1147-51. PubMed PMID: 7628959. 5: Chang WJ, Barb CR, Kraeling RR, Rampacek GB, Leshin LS. Involvement of the central noradrenergic system in opioid modulation of luteinizing hormone and prolactin secretion in the pig. Biol Reprod. 1993 Jul;49(1):176-80. PubMed PMID: 8353185. 6: Küneke G, Parvizi N, Elsaesser F. Effect of naloxone and pulsatile luteinizing-hormone-releasing hormone infusions on oestradiol-induced luteinizing hormone surges in immature gilts. J Reprod Fertil. 1993 Mar;97(2):395-401. PubMed PMID: 8501710. 7: Elsaesser F, Parvizi N, Foxcroft GR. Control of the LH surge mechanism in the female pig. J Physiol Pharmacol. 1992 Dec;43(4 Suppl 1):69-78. Review. PubMed PMID: 1343977. 8: Paczoska-Eliasiewicz H, Rzasa J. Serotonin levels in the hen ovarian follicles after methallibure (I.C.I 33, 828) treatment. Zentralbl Veterinarmed A. 1991 Apr;38(3):187-93. PubMed PMID: 1907063. 9: Campbell SM, Wiebe JP. Stimulation of spermatocyte development in prepubertal rats by the Sertoli cell steroid, 3 alpha-hydroxy-4-pregnen-20-one. Biol Reprod. 1989 Apr;40(4):897-905. PubMed PMID: 2502196. 10: Lusky K, Bache K, Zwies G. [The fertility performance (litter characteristics) of laboratory mice over 6 generations after the administration of zinc metallibure as suisynchronous premix and cloprostenol as estrophane]. Arch Exp Veterinarmed. 1989 Jan;43(1):147-54. German. PubMed PMID: 2505726. 11: Löw O, Bachmann H. Morphometric investigations on endocrine glands. VI. Changes in rat pituitary glands after ovarectomy and a single injection of estradiol benzoate once per cycle period. Exp Pathol. 1988;33(3):193-5. PubMed PMID: 3224680. 12: Kesner JS, Kraeling RR, Rampacek GB, Johnson B. Absence of an estradiol-induced surge of luteinizing hormone in pigs receiving unvarying pulsatile gonadotropin-releasing hormone stimulation. Endocrinology. 1987 Nov;121(5):1862-9. PubMed PMID: 3117524. 13: Kesner JS, Kraeling RR, Rampacek GB, Barb CR, Estienne MS, Kineman RD, Estienne CE. On the site of action of the estradiol-induced release of luteinizing hormone (LH) in pigs. Adv Exp Med Biol. 1987;219:653-7. PubMed PMID: 3324689. 14: Lam TJ, Pavri C, Ng KL. Effect of methallibure on gestation in the guppy, Poecilia reticulata. Gen Comp Endocrinol. 1985 Nov;60(2):315-23. PubMed PMID: 3934030. 15: Guthrie HD. Control of time of parturition in pigs. J Reprod Fertil Suppl. 1985;33:229-44. Review. PubMed PMID: 2868126. 16: Bergfeld J, Brüssow KP, George G. [Ovulation dynamics and potency in groups of gilts on various farms following different treatments for the stimulation of ovulation]. Arch Exp Veterinarmed. 1984 Sep;38(5):735-43. German. PubMed PMID: 6397157. 17: Jahn GA, Burdman JA, Deis RP. Regulation of pituitary DNA synthesis during different reproductive states in the female rat: role of estrogens and prolactin. Mol Cell Endocrinol. 1984 May;35(2-3):113-9. PubMed PMID: 6734926. 18: Schwerin M, Braun R, Schöneich J, Kauffold P. [Induction of dominant lethal mutations in laboratory rats following cycle blockade by Suisynchron premix. 4. Mutagenicity studies of the gestogen Suisynchron in bacterial test systems]. Arch Exp Veterinarmed. 1984 Mar;38(2):272-7. German. PubMed PMID: 6430254. 19: Schwerin M, Renne U. [Induction of dominant lethal mutations in laboratory rats following cycle blockage with Suisynchron premix. 3. Chromosome aberrations in embryonic stages of treated animals and untreated daughters]. Arch Exp Veterinarmed. 1982;36(5):767-74. German. PubMed PMID: 6819836. 20: Schwerin M, Renne U. [Induction of dominant lethal mutations in laboratory rats following cycle blockage with Suisynchron premix. 2. Chromosome aberrations in unfertilized ovulated oocytes of treated laboratory rats]. Arch Exp Veterinarmed. 1982;36(5):759-66. German. PubMed PMID: 6819835.