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MedKoo Cat#: 572528 | Name: Hydroxy-Amino-bis(PEG1-t-butyl ester)
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Hydroxy-Amino-bis(PEG1-t-butyl ester) is a branched PEG derivative with a terminal hydroxy group and two t-butyl esters. The hydroxy group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl groups can be deprotected under mild acidic conditions.

Chemical Structure

Hydroxy-Amino-bis(PEG1-t-butyl ester)
Hydroxy-Amino-bis(PEG1-t-butyl ester)
CAS#1415800-34-8

Theoretical Analysis

MedKoo Cat#: 572528

Name: Hydroxy-Amino-bis(PEG1-t-butyl ester)

CAS#: 1415800-34-8

Chemical Formula: C20H39NO7

Exact Mass: 405.2727

Molecular Weight: 405.53

Elemental Analysis: C, 59.24; H, 9.69; N, 3.45; O, 27.62

Price and Availability

Size Price Availability Quantity
500mg USD 550.00 2 Weeks
1g USD 950.00 2 Weeks
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Related CAS #
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Synonym
Hydroxy-Amino-bis(PEG1-t-butyl ester)
IUPAC/Chemical Name
di-tert-butyl 3,3'-((((2-hydroxyethyl)azanediyl)bis(ethane-2,1-diyl))bis(oxy))dipropionate
InChi Key
OUIZBEKRHPKXAD-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H39NO7/c1-19(2,3)27-17(23)7-13-25-15-10-21(9-12-22)11-16-26-14-8-18(24)28-20(4,5)6/h22H,7-16H2,1-6H3
SMILES Code
OCCN(CCOCCC(OC(C)(C)C)=O)CCOCCC(OC(C)(C)C)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 405.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Brown A, Patel S, Ward C, Lorenz A, Ortiz M, DuRoss A, Wieghardt F, Esch A, Otten EG, Heiser LM, Korolchuk VI, Sun C, Sarkar S, Sahay G. PEG-lipid micelles enable cholesterol efflux in Niemann-Pick Type C1 disease-based lysosomal storage disorder. Sci Rep. 2016 Aug 30;6:31750. doi: 10.1038/srep31750. PubMed PMID: 27572704; PubMed Central PMCID: PMC5004151. 2: Saifer MG, Williams LD, Sobczyk MA, Michaels SJ, Sherman MR. Selectivity of binding of PEGs and PEG-like oligomers to anti-PEG antibodies induced by methoxyPEG-proteins. Mol Immunol. 2014 Feb;57(2):236-46. doi: 10.1016/j.molimm.2013.07.014. Epub 2013 Nov 5. PubMed PMID: 24200843. 3: Garay RP, El-Gewely R, Armstrong JK, Garratty G, Richette P. Antibodies against polyethylene glycol in healthy subjects and in patients treated with PEG-conjugated agents. Expert Opin Drug Deliv. 2012 Nov;9(11):1319-23. doi: 10.1517/17425247.2012.720969. Epub 2012 Aug 30. PubMed PMID: 22931049.