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MedKoo Cat#: 593074 | Name: Nortriptyline

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Nortriptyline is a metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.

Chemical Structure

Nortriptyline
Nortriptyline
CAS#72-69-5

Theoretical Analysis

MedKoo Cat#: 593074

Name: Nortriptyline

CAS#: 72-69-5

Chemical Formula: C19H21N

Exact Mass: 263.1674

Molecular Weight: 263.38

Elemental Analysis: C, 86.64; H, 8.04; N, 5.32

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Nortriptyline
IUPAC/Chemical Name
1-Propanamine, 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N-methyl-
InChi Key
PHVGLTMQBUFIQQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-11,20H,6,12-14H2,1H3
SMILES Code
CNCC/C=C1C2=CC=CC=C2CCC3=CC=CC=C\13
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 263.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Bethesda (MD): National Library of Medicine (US); 2006-. Available from http://www.ncbi.nlm.nih.gov/books/NBK501176/ PubMed PMID: 30000235. 5: Caldara M, Marmiroli N. Tricyclic antidepressants inhibit Candida albicans growth and biofilm formation. Int J Antimicrob Agents. 2018 Jul 7. pii: S0924-8579(18)30191-2. doi: 10.1016/j.ijantimicag.2018.06.023. [Epub ahead of print] PubMed PMID: 29990546. 6: Siafis S, Papazisis G. Detecting a potential safety signal of antidepressants and type 2 diabetes: a pharmacovigilance-pharmacodynamic study. Br J Clin Pharmacol. 2018 Jun 28. doi: 10.1111/bcp.13699. [Epub ahead of print] PubMed PMID: 29953643. 7: Tylutki Z, Mendyk A, Polak S. Physiologically based pharmacokinetic-quantitative systems toxicology and safety (PBPK-QSTS) modeling approach applied to predict the variability of amitriptyline pharmacokinetics and cardiac safety in populations and in individuals. J Pharmacokinet Pharmacodyn. 2018 Jun 25. doi: 10.1007/s10928-018-9597-6. [Epub ahead of print] PubMed PMID: 29943290. 8: Gawecka E, Viken O. Postherpetic neuralgia: New hopes in prevention with adult vaccination and in treatment with a concentrated capsaicin patch. Scand J Pain. 2012 Oct 1;3(4):220-228. doi: 10.1016/j.sjpain.2012.05.070. PubMed PMID: 29913873. 9: Ma LD, Li J, Li JJ, Liu M, Yan DZ, Shi WY, Xu G. Occurrence and source analysis of selected antidepressants and their metabolites in municipal wastewater and receiving surface water. Environ Sci Process Impacts. 2018 Jul 18;20(7):1020-1029. doi: 10.1039/c8em00077h. PubMed PMID: 29897361. 10: Kharade SV, Kurata H, Bender AM, Blobaum AL, Figueroa EE, Duran A, Kramer M, Days E, Vinson P, Flores D, Satlin LM, Meiler J, Weaver CD, Lindsley CW, Hopkins CR, Denton JS. Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992. Mol Pharmacol. 2018 Aug;94(2):926-937. doi: 10.1124/mol.118.112359. Epub 2018 Jun 12. PubMed PMID: 29895592. 11: Deng L, Qiu S, Yang Y, Wang L, Li Y, Lin J, Wei Q, Yang L, Wang D, Liu M. Efficacy and tolerability of pharmacotherapy for post-stroke depression: a network meta-analysis. Oncotarget. 2018 Jan 3;9(34):23718-23728. doi: 10.18632/oncotarget.23891. eCollection 2018 May 4. PubMed PMID: 29805769; PubMed Central PMCID: PMC5955092. 12: Leite Pacheco R, de Oliveira Cruz Latorraca C, Adriano Leal Freitas da Costa A, Luiza Cabrera Martimbianco A, Vianna Pachito D, Riera R. Melatonin for preventing primary headache: A systematic review. Int J Clin Pract. 2018 Jul;72(7):e13203. doi: 10.1111/ijcp.13203. Epub 2018 May 24. Review. PubMed PMID: 29799148. 13: Øiestad ÅML, Karinen R, Rogde S, Nilsen S, Boye Eldor KB, Brochmann GW, Arnestad M, Øiestad EL, Peres MD, Kristoffersen L, Vindenes V. Comparative Study of Postmortem Concentrations of Antidepressants in Several Different Matrices. J Anal Toxicol. 2018 Sep 1;42(7):446-458. doi: 10.1093/jat/bky030. PubMed PMID: 29762694. 14: Qin B, Chen H, Gao W, Zhao LB, Zhao MJ, Qin HX, Chen W, Chen L, Yang MX. Efficacy, acceptability, and tolerability of antidepressant treatments for patients with post-stroke depression: a network meta-analysis. Braz J Med Biol Res. 2018;51(7):e7218. doi: 10.1590/1414-431x20187218. Epub 2018 May 7. Review. PubMed PMID: 29742266; PubMed Central PMCID: PMC5972011. 15: Rossi FH, Gonzalez E, Rossi EM, Tsakadze N. Exploding Head Syndrome as Aura of Migraine with Brainstem Aura: A Case Report. J Oral Facial Pain Headache. 2018 Spring;32(2):e34-e36. doi: 10.11607/ofph.1950. PubMed PMID: 29694468. 16: Usach I, Ferrer JM, Peris JE. In vitro assessment of competitive and time-dependent inhibition of the nevirapine metabolism by nortriptyline in rats. Biochem Pharmacol. 2018 Aug;154:1-9. doi: 10.1016/j.bcp.2018.04.016. Epub 2018 Apr 17. PubMed PMID: 29674001. 17: Molyneaux E, Telesia LA, Henshaw C, Boath E, Bradley E, Howard LM. Antidepressants for preventing postnatal depression. Cochrane Database Syst Rev. 2018 Apr 18;4:CD004363. doi: 10.1002/14651858.CD004363.pub3. Review. PubMed PMID: 29669175. 18: Bowen AJ, Nowacki AS, Contrera K, Trask D, Kaltenbach J, Milstein CF, Adessa M, Benninger MS, Taliercio R, Bryson PC. Short- and Long-term Effects of Neuromodulators for Unexplained Chronic Cough. Otolaryngol Head Neck Surg. 2018 Apr 1:194599818768517. doi: 10.1177/0194599818768517. [Epub ahead of print] PubMed PMID: 29634404. 19: Choi JW, Zhao Y, Bediako JK, Cho CW, Yun YS. Estimating environmental fate of tricyclic antidepressants in wastewater treatment plant. Sci Total Environ. 2018 Sep 1;634:52-58. doi: 10.1016/j.scitotenv.2018.03.278. Epub 2018 Apr 5. PubMed PMID: 29626770. 20: Iniesta R, Hodgson K, Stahl D, Malki K, Maier W, Rietschel M, Mors O, Hauser J, Henigsberg N, Dernovsek MZ, Souery D, Dobson R, Aitchison KJ, Farmer A, McGuffin P, Lewis CM, Uher R. 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