Sparstolonin B | CAS#1259330-61-4 | TLR2/4 antagonist

MedKoo Cat#: 563749 | Name: Sparstolonin B

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sparstolonin B is a potent TLR2 and TLR4 antagonist, exhibiting anti-inflammatory and anti-viral (anti-HIV) properties.

Chemical Structure

Sparstolonin B

CAS#1259330-61-4

Theoretical Analysis

MedKoo Cat#: 563749

Name: Sparstolonin B

CAS#: 1259330-61-4

Chemical Formula: C15H8O5

Exact Mass: 268.0372

Molecular Weight: 268.22

Elemental Analysis: C, 67.17; H, 3.01; O, 29.82

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Sparstolonin B; Sparstolonin-B; SsnB; Sparstolenin B;

IUPAC/Chemical Name

4,10-Dihydroxy-3H-pyrano[3,4,5-kl]xanthen-3-one

InChi Key

DHSASSJDMAHICE-UHFFFAOYSA-N

InChi Code

InChI=1S/C15H8O5/c16-7-1-3-11-8(5-7)9-6-19-15(18)14-10(17)2-4-12(20-11)13(9)14/h1-6,16-17H

SMILES Code

O=C1OC=C2C3=C(OC4=C2C1=C(O)C=C4)C=CC(O)=C3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 268.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Wang Y, Jiang S, Xiao J, Liang Q, Tang M. Sparstolonin B improves neurological outcomes following intracerebral hemorrhage in mice. Exp Ther Med. 2018 Jun;15(6):5436-5442. doi: 10.3892/etm.2018.6092. Epub 2018 Apr 24. PubMed PMID: 29844805; PubMed Central PMCID: PMC5958797. 2: Yuan J, Zhang X, Zhu R, Cui Z, Hu W. Sparstolonin B attenuates spinal cord injury induced inflammation in rats by modulating TLR4 trafficking. Mol Med Rep. 2018 Apr;17(4):6016-6022. doi: 10.3892/mmr.2018.8561. Epub 2018 Feb 6. PubMed PMID: 29436632. 3: Tang YM, Cao QY, Guo XY, Dong SH, Duan JA, Wu QN, Liang QL. Inhibition of p38 and ERK1/2 pathways by Sparstolonin B suppresses inflammation-induced melanoma metastasis. Biomed Pharmacother. 2018 Feb;98:382-389. doi: 10.1016/j.biopha.2017.12.047. Epub 2017 Dec 27. PubMed PMID: 29276966. 4: Jin G, Jin X, Zhou S. Sparstolonin B selectively suppresses toll like receptor 2 and 4 to alleviate neuropathic pain. Mol Med Rep. 2018 Jan;17(1):1247-1252. doi: 10.3892/mmr.2017.7951. Epub 2017 Nov 3. PubMed PMID: 29115627. 5: Ge J, Chen L, Yang Y, Lu X, Xiang Z. Sparstolonin B prevents lumbar intervertebral disc degeneration through toll like receptor 4, NADPH oxidase activation and the protein kinase B signaling pathway. Mol Med Rep. 2018 Jan;17(1):1347-1353. doi: 10.3892/mmr.2017.7966. Epub 2017 Nov 6. PubMed PMID: 29115481. 6: Zhong Q, Zhou K, Liang QL, Lin S, Wang YC, Xiong XY, Meng ZY, Zhao T, Zhu WY, Yang YR, Liao MF, Gong QW, Liu L, Xiong A, Hao J, Wang J, Yang QW. Interleukin-23 Secreted by Activated Macrophages Drives γδT Cell Production of Interleukin-17 to Aggravate Secondary Injury After Intracerebral Hemorrhage. J Am Heart Assoc. 2016 Oct 11;5(10). pii: e004340. PubMed PMID: 27729335; PubMed Central PMCID: PMC5121525. 7: Kumar A, Fan D, DiPette DJ, Singh US. Correction: Sparstolonin B, a Novel Plant Derived Compound, Arrests Cell Cycle and Induces Apoptosis in N-Myc Amplified and N-Myc Nonamplified Neuroblastoma Cells. PLoS One. 2016 Jul 6;11(7):e0159082. doi: 10.1371/journal.pone.0159082. eCollection 2016. PubMed PMID: 27384668; PubMed Central PMCID: PMC4934772. 8: Dattaroy D, Seth RK, Das S, Alhasson F, Chandrashekaran V, Michelotti G, Fan D, Nagarkatti M, Nagarkatti P, Diehl AM, Chatterjee S. Sparstolonin B attenuates early liver inflammation in experimental NASH by modulating TLR4 trafficking in lipid rafts via NADPH oxidase activation. Am J Physiol Gastrointest Liver Physiol. 2016 Apr 1;310(7):G510-25. doi: 10.1152/ajpgi.00259.2015. Epub 2015 Dec 30. PubMed PMID: 26718771; PubMed Central PMCID: PMC4824178. 9: Tuorkey MJ. Cancer Therapy with Phytochemicals: Present and Future Perspectives. Biomed Environ Sci. 2015 Nov;28(11):808-19. doi: 10.3967/bes2015.112. Review. PubMed PMID: 26695359. 10: Wang M, Xiu L, Diao J, Wei L, Sun J. Sparstolonin B inhibits lipopolysaccharide-induced inflammation in 3T3-L1 adipocytes. Eur J Pharmacol. 2015 Dec 15;769:79-85. doi: 10.1016/j.ejphar.2015.10.050. Epub 2015 Oct 30. PubMed PMID: 26522926. 11: Deng X, Zhang Y, Jiang F, Chen R, Peng P, Wen B, Liang J. The Chinese herb-derived Sparstolonin B suppresses HIV-1 transcription. Virol J. 2015 Jul 25;12:108. doi: 10.1186/s12985-015-0339-8. PubMed PMID: 26206295; PubMed Central PMCID: PMC4513614. 12: Liu Q, Li J, Liang Q, Wang D, Luo Y, Yu F, Janicki JS, Fan D. Sparstolonin B suppresses rat vascular smooth muscle cell proliferation, migration, inflammatory response and lipid accumulation. Vascul Pharmacol. 2015 Apr-Jun;67-69:59-66. doi: 10.1016/j.vph.2015.03.015. Epub 2015 Apr 11. PubMed PMID: 25869499; PubMed Central PMCID: PMC4433853. 13: Zou NS, Liang QL, Li P, Liu J, Liu X, Kang A, Deng HS. Determination of sparstolonin B by ultra-high performance liquid chromatography coupled with triple quadrupole mass spectrometry: application to pharmacokinetic study of sparstolonin B in rat plasma. Biomed Chromatogr. 2015 Oct;29(10):1486-91. doi: 10.1002/bmc.3447. Epub 2015 Mar 2. PubMed PMID: 25731641. 14: Liang Q, Dong S, Lei L, Liu J, Zhang J, Li J, Duan J, Fan D. Protective effects of Sparstolonin B, a selective TLR2 and TLR4 antagonist, on mouse endotoxin shock. Cytokine. 2015 Oct;75(2):302-9. doi: 10.1016/j.cyto.2014.12.003. Epub 2015 Jan 5. PubMed PMID: 25573805; PubMed Central PMCID: PMC4950682. 15: Li P, Liang QL, Cui XD, Li J, Zou NS, Wu QN, Duan JA. Protective effects of the active fraction from the tuber of Scirpus yagara in mouse endotoxin shock model. J Ethnopharmacol. 2014 Dec 2;158 Pt A:331-7. doi: 10.1016/j.jep.2014.10.032. Epub 2014 Oct 31. PubMed PMID: 25446641. 16: Liu Q, Li J, Jubair S, Wang D, Luo Y, Fan D, Janicki JS. Sparstolonin B attenuates hypoxia-induced apoptosis, necrosis and inflammation in cultured rat left ventricular tissue slices. Cardiovasc Drugs Ther. 2014 Oct;28(5):433-9. doi: 10.1007/s10557-014-6545-6. PubMed PMID: 25117676; PubMed Central PMCID: PMC4164598. 17: Kumar A, Fan D, Dipette DJ, Singh US. Sparstolonin B, a novel plant derived compound, arrests cell cycle and induces apoptosis in N-myc amplified and N-myc nonamplified neuroblastoma cells. PLoS One. 2014 May 1;9(5):e96343. doi: 10.1371/journal.pone.0096343. eCollection 2014. Erratum in: PLoS One. 2016;11(7):e0159082. PubMed PMID: 24788776; PubMed Central PMCID: PMC4006872. 18: Liu Q, Wang J, Liang Q, Wang D, Luo Y, Li J, Janicki JS, Fan D. Sparstolonin B attenuates hypoxia-reoxygenation-induced cardiomyocyte inflammation. Exp Biol Med (Maywood). 2014 Mar;239(3):376-84. doi: 10.1177/1535370213517620. Epub 2014 Jan 29. PubMed PMID: 24477822. 19: Bateman HR, Liang Q, Fan D, Rodriguez V, Lessner SM. Sparstolonin B inhibits pro-angiogenic functions and blocks cell cycle progression in endothelial cells. PLoS One. 2013 Aug 5;8(8):e70500. doi: 10.1371/journal.pone.0070500. Print 2013. PubMed PMID: 23940584; PubMed Central PMCID: PMC3734268. 20: Liang Q, Yu F, Cui X, Duan J, Wu Q, Nagarkatti P, Fan D. Sparstolonin B suppresses lipopolysaccharide-induced inflammation in human umbilical vein endothelial cells. Arch Pharm Res. 2013 Jul;36(7):890-6. doi: 10.1007/s12272-013-0120-8. Epub 2013 Apr 20. PubMed PMID: 23604718; PubMed Central PMCID: PMC4145723.