ABC44 is a potent and selective inhibitor of palmitoyl-protein thioesterase 1 (PPT-1) with notably more activity in situ than in vitro. ABC44 showed potent, dose-dependent inhibition of an ABC45-reactive protein matching the molecular mass of deglycosylated PPT1 in PNGaseF-treated central and peripheral tissues, producing near-complete blockade of this enzyme activity at 1–5 mg/kg. ABC44 showed excellent selectivity for PPT1 and did not inhibit other SHs detected in brain and testis tissues treated with the FP-Rh or ABC45 probes.
MedKoo Cat#: 563742
Name: ABC44
CAS#: 1831135-46-6
Chemical Formula: C31H40N6O5
Exact Mass: 576.3060
Molecular Weight: 576.69
Elemental Analysis: C, 64.56; H, 6.99; N, 14.57; O, 13.87
The following data is based on the product molecular weight 576.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
