Synonym
Atiprosin maleate; AY-28,228; AY 28,228; AY28,228
IUPAC/Chemical Name
Pyrazino(2',3':3,4)pyrido(1,2-a)indole, 1-ethyl-1,2,3,4,4a,5,6,12b-octahydro-12-methyl-4-(1-methylethyl)-, trans, (z)-2-butenedioate(1:1)
InChi Key
MPSLGGPOYBRWKD-ZKUJQEIMSA-N
InChi Code
InChI=1S/C20H29N3.C4H4O4/c1-5-21-12-13-22(14(2)3)18-10-11-23-17-9-7-6-8-16(17)15(4)19(23)20(18)21;5-3(6)1-2-4(7)8/h6-9,14,18,20H,5,10-13H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t18-,20+;/m1./s1
SMILES Code
CCN1CCN([C@@H]2CCn(c([C@@H]12)c3C)c4c3cccc4)C(C)C.OC(/C=C\C(O)=O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
427.55
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Oshiro G, Wojdan A, Klein M, Metcalf G. Antihypertensive and hypotensive actions of atiprosin (AY-28,228) in rats, dogs, and monkeys. J Cardiovasc Pharmacol. 1987 Sep;10(3):341-9. PubMed PMID: 2444784.
2: Grimes D, Rimele TJ, Henry DE, Heaslip RJ, Geiger G, Lee DK, Metcalf G. In vitro isolated tissue studies with atiprosin (AY-28,228): a new antihypertensive compound. J Cardiovasc Pharmacol. 1987 Sep;10(3):249-58. PubMed PMID: 2444771.
3: Jirkovsky I, Santroch G, Baudy R, Oshiro G. Octahydropyrazino[2',3':3,4]pyrido[1,2-a]indoles. A new class of potent antihypertensive agents. J Med Chem. 1987 Feb;30(2):388-94. PubMed PMID: 3806618.
