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MedKoo Cat#: 461919 | Name: Schizandrin C
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Schizandrin C is a compound that exerts anti-neuroinflammatory effects by upregulating phase II detoxifying/antioxidant enzymes in microglia.

Chemical Structure

Schizandrin C
Schizandrin C
CAS#61301-33-5

Theoretical Analysis

MedKoo Cat#: 461919

Name: Schizandrin C

CAS#: 61301-33-5

Chemical Formula: C22H24O6

Exact Mass: 384.1573

Molecular Weight: 384.42

Elemental Analysis: C, 68.74; H, 6.29; O, 24.97

Price and Availability

Size Price Availability Quantity
1mg USD 240.00
5mg USD 545.00
10mg USD 865.00
25mg USD 1,600.00
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Related CAS #
No Data
Synonym
Schizandrin C; Schizandrin-C; Wuweizisu C
IUPAC/Chemical Name
(6R,7S,13aS)-5,6,7,8-tetrahydro-13,14-dimethoxy-6,7-dimethyl-cycloocta[1,2-f:3,4-f']bis[1,3]benzodioxole
InChi Key
HTBWBWWADZJXID-TXEJJXNPSA-N
InChi Code
InChI=1S/C22H24O6/c1-11-5-13-7-15-19(27-9-25-15)21(23-3)17(13)18-14(6-12(11)2)8-16-20(22(18)24-4)28-10-26-16/h7-8,11-12H,5-6,9-10H2,1-4H3/t11-,12+
SMILES Code
C[C@H]([C@H](C)C1)CC2=C(C3=C1C=C4OCOC4=C3OC)C(OC)=C5OCOC5=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Schizandrin C is a molecular glue. Schizandrin C is used for cancer, Alzheimer’s disease, and liver diseases research. Schizandrin C induces cell apoptosis.
In vitro activity:
Schizandrin C may be useful in preventing obesity and metabolic diseases; Schizandrin C-containing foods may be a dietary strategy. In this study, Schizandrin C significantly reduces adipocyte differentiation in 3T3-L1 cells without affecting cell proliferation. SC lowers total lipid and triglyceride contents, down-regulates adipogenic gene expressions, increases p-AMPK, regulates adipogenic transcription factors, and inhibits lipolysis-related genes and pancreatic lipase levels. Reference: J Food Biochem. 2022 Dec;46(12):e14454. https://pubmed.ncbi.nlm.nih.gov/36200699/
In vivo activity:
Schizandrin C has potential as a drug for liver fibrosis. In a murine model of liver fibrosis, Schizandrin C exerted an anti-hepatic fibrosis effect and reduced the expressions of alpha-smooth muscle actin and type Ι collagen in the liver. Schizandrin C can regulate lipid metabolism and inflammation to ameliorate liver fibrosis by nuclear factor kappa-B and p38/ERK MAPK signaling pathways. Reference: Front Pharmacol. 2023 May 23;14:1092151. https://pubmed.ncbi.nlm.nih.gov/37288106/
Solvent mg/mL mM
Solubility
DMSO 8.3 21.67
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 384.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Jang M, Choi SI. Schisandrin C isolated from Schisandra chinensis fruits inhibits lipid accumulation by regulating adipogenesis and lipolysis through AMPK signaling in 3T3-L1 adipocytes. J Food Biochem. 2022 Dec;46(12):e14454. doi: 10.1111/jfbc.14454. Epub 2022 Oct 6. PMID: 36200699. 2. Park SY, Park SJ, Park TG, Rajasekar S, Lee SJ, Choi YW. Schizandrin C exerts anti-neuroinflammatory effects by upregulating phase II detoxifying/antioxidant enzymes in microglia. Int Immunopharmacol. 2013 Oct;17(2):415-26. doi: 10.1016/j.intimp.2013.06.032. Epub 2013 Jul 13. PMID: 23859871. 3. Chen P, Wang R, Liu F, Li S, Gu Y, Wang L, Yuan Y. Schizandrin C regulates lipid metabolism and inflammation in liver fibrosis by NF-κB and p38/ERK MAPK signaling pathways. Front Pharmacol. 2023 May 23;14:1092151. doi: 10.3389/fphar.2023.1092151. PMID: 37288106; PMCID: PMC10242051. 4. Dai WZ, Bai ZF, He TT, Zhan XY, Li Q, Zhao J, Xiao XH. [Schisandrin C improves acetaminophen-induced liver injury in mice by regulating Nrf2 signaling pathway]. Zhongguo Zhong Yao Za Zhi. 2022 Oct;47(19):5299-5305. Chinese. doi: 10.19540/j.cnki.cjcmm.20220421.704. PMID: 36472037.
In vitro protocol:
1. Jang M, Choi SI. Schisandrin C isolated from Schisandra chinensis fruits inhibits lipid accumulation by regulating adipogenesis and lipolysis through AMPK signaling in 3T3-L1 adipocytes. J Food Biochem. 2022 Dec;46(12):e14454. doi: 10.1111/jfbc.14454. Epub 2022 Oct 6. PMID: 36200699. 2. Park SY, Park SJ, Park TG, Rajasekar S, Lee SJ, Choi YW. Schizandrin C exerts anti-neuroinflammatory effects by upregulating phase II detoxifying/antioxidant enzymes in microglia. Int Immunopharmacol. 2013 Oct;17(2):415-26. doi: 10.1016/j.intimp.2013.06.032. Epub 2013 Jul 13. PMID: 23859871.
In vivo protocol:
1. Chen P, Wang R, Liu F, Li S, Gu Y, Wang L, Yuan Y. Schizandrin C regulates lipid metabolism and inflammation in liver fibrosis by NF-κB and p38/ERK MAPK signaling pathways. Front Pharmacol. 2023 May 23;14:1092151. doi: 10.3389/fphar.2023.1092151. PMID: 37288106; PMCID: PMC10242051. 2. Dai WZ, Bai ZF, He TT, Zhan XY, Li Q, Zhao J, Xiao XH. [Schisandrin C improves acetaminophen-induced liver injury in mice by regulating Nrf2 signaling pathway]. Zhongguo Zhong Yao Za Zhi. 2022 Oct;47(19):5299-5305. Chinese. doi: 10.19540/j.cnki.cjcmm.20220421.704. PMID: 36472037.
1: Park SY, Park SJ, Park TG, Rajasekar S, Lee SJ, Choi YW. Schizandrin C exerts anti-neuroinflammatory effects by upregulating phase II detoxifying/antioxidant enzymes in microglia. Int Immunopharmacol. 2013 Oct;17(2):415-26. doi: 10.1016/j.intimp.2013.06.032. Epub 2013 Jul 13. PubMed PMID: 23859871. 2: Xie JX, Zhou J, Zhang CZ, Yang JH, Chen JX. Studies on antihepatitic drugs. Total synthesis of (+/-)schizandrin C and its analogs. Sci Sin B. 1983 Dec;26(12):1291-303. PubMed PMID: 6673110. 3: Choi YW, Kim K, Jo JY, Kim HL, Lee YJ, Shin WJ, Sacket SJ, Han M, Im DS. Wuweizisu C from Schisandra chinensis decreases membrane potential in C6 glioma cells. Acta Pharmacol Sin. 2008 Sep;29(9):1006-12. doi: 10.1111/j.1745-7254.2008.00838.x. PubMed PMID: 18718168. 4: Song JH, Cui L, An LB, Li WT, Fang ZZ, Zhang YY, Dong PP, Wu X, Wang LX, Gonzalez FJ, Sun XY, Zhao DW. Inhibition of UDP-Glucuronosyltransferases (UGTs) Activity by constituents of Schisandra chinensis. Phytother Res. 2015 Oct;29(10):1658-64. doi: 10.1002/ptr.5395. Epub 2015 Jun 18. PubMed PMID: 26084208. 5: Oh SY, Kim YH, Bae DS, Um BH, Pan CH, Kim CY, Lee HJ, Lee JK. Anti-inflammatory effects of gomisin N, gomisin J, and schisandrin C isolated from the fruit of Schisandra chinensis. Biosci Biotechnol Biochem. 2010;74(2):285-91. Epub 2010 Feb 7. PubMed PMID: 20139628. 6: Park C, Choi YW, Hyun SK, Kwon HJ, Hwang HJ, Kim GY, Choi BT, Kim BW, Choi IW, Moon SK, Kim WJ, Choi YH. Induction of G1 arrest and apoptosis by schisandrin C isolated from Schizandra chinensis Baill in human leukemia U937 cells. Int J Mol Med. 2009 Oct;24(4):495-502. PubMed PMID: 19724890.