Bretylium tosylate | CAS#61-75-6 | anti-arrhythmic

MedKoo Cat#: 592986 | Name: Bretylium tosylate

Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Bretylium tosylate is an agent that blocks the release of adrenergic transmitters and may have other actions. It was formerly used as an antihypertensive agent, but is now proposed as an anti-arrhythmic.

Chemical Structure

Bretylium tosylate

CAS#61-75-6

Theoretical Analysis

MedKoo Cat#: 592986

Name: Bretylium tosylate

CAS#: 61-75-6

Chemical Formula: C18H24BrNO3S

Exact Mass: 413.0660

Molecular Weight: 414.36

Elemental Analysis: C, 52.18; H, 5.84; Br, 19.28; N, 3.38; O, 11.58; S, 7.74

Price and Availability

Size	Price	Availability	Quantity
50mg	USD 450.00	2 Weeks
100mg	USD 650.00	2 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

No Data

Synonym

Bretylium tosylate

IUPAC/Chemical Name

Ammonium, (o-bromobenzyl)ethyldimethyl-, p-toluenesulfonate

InChi Key

KVWNWTZZBKCOPM-UHFFFAOYSA-M

InChi Code

InChI=1S/C11H17BrN.C7H8O3S/c1-4-13(2,3)9-10-7-5-6-8-11(10)12;1-6-2-4-7(5-3-6)11(8,9)10/h5-8H,4,9H2,1-3H3;2-5H,1H3,(H,8,9,10)/q+1;/p-1

SMILES Code

C[N+](CC)(CC1=CC=CC=C1Br)C.CC2=CC=C(S(=O)([O-])=O)C=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 414.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Amano T, Fujii N, Inoue Y, Kondo N. Cutaneous adrenergic nerve blockade attenuates sweating during incremental exercise in habitually trained men. J Appl Physiol (1985). 2018 Jul 19. doi: 10.1152/japplphysiol.00370.2018. [Epub ahead of print] PubMed PMID: 30024338. 2: Hodges GJ, Mallette MM, Martin ZT, Del Pozzi AT. Effect of sympathetic nerve blockade on low-frequency oscillations of forearm and leg skin blood flow in healthy humans. Microcirculation. 2017 Oct;24(7). doi: 10.1111/micc.12388. PubMed PMID: 28627137. 3: Hodges GJ, Martin ZT, Del Pozzi AT. Neuropeptide Y not involved in cutaneous vascular control in young human females taking oral contraceptive hormones. Microvasc Res. 2017 Sep;113:9-15. doi: 10.1016/j.mvr.2017.04.003. Epub 2017 Apr 18. PubMed PMID: 28427990. 4: Del Pozzi AT, Hodges GJ. Comparison of the noradrenergic sympathetic nerve contribution during local skin heating at forearm and leg sites in humans. Eur J Appl Physiol. 2015 May;115(5):1155-64. doi: 10.1007/s00421-014-3097-1. Epub 2015 Jan 9. PubMed PMID: 25572497. 5: Del Pozzi AT, Hodges GJ. To reheat, or to not reheat: that is the question: the efficacy of a local reheating protocol on mechanisms of cutaneous vasodilatation. Microvasc Res. 2015 Jan;97:47-54. doi: 10.1016/j.mvr.2014.09.006. Epub 2014 Oct 2. PubMed PMID: 25281012. 6: McGinn R, Fujii N, Swift B, Lamarche DT, Kenny GP. Adenosine receptor inhibition attenuates the suppression of postexercise cutaneous blood flow. J Physiol. 2014 Jun 15;592(12):2667-78. doi: 10.1113/jphysiol.2014.274068. Epub 2014 Mar 31. PubMed PMID: 24687586; PubMed Central PMCID: PMC4080945. 7: Hodges GJ, Sparks PA. Contributions of endothelial nitric oxide synthase, noradrenaline, and neuropeptide Y to local warming-induced cutaneous vasodilatation in men. Microvasc Res. 2013 Nov;90:128-34. doi: 10.1016/j.mvr.2013.08.011. Epub 2013 Sep 6. PubMed PMID: 24012636. 8: Sveshnikov DS, Smirnov VM, Myasnikov IL, Mongush MI, Yurasova IA. Catecholamines, α-, and β-adrenoceptors are not responsible for activation of duodenum motility induced by sympathetic nerve stimulation. Bull Exp Biol Med. 2011 Nov;152(1):5-8. English, Russian. PubMed PMID: 22803025. 9: Yamazaki F. Oral vitamin C enhances the adrenergic vasoconstrictor response to local cooling in human skin. J Appl Physiol (1985). 2012 May;112(10):1689-97. doi: 10.1152/japplphysiol.00043.2012. Epub 2012 Mar 1. PubMed PMID: 22383508. 10: Carter SJ, Hodges GJ. Sensory and sympathetic nerve contributions to the cutaneous vasodilator response from a noxious heat stimulus. Exp Physiol. 2011 Nov;96(11):1208-17. doi: 10.1113/expphysiol.2011.059907. Epub 2011 Sep 2. PubMed PMID: 21890519. 11: Tew GA, Saxton JM, Klonizakis M, Moss J, Ruddock AD, Hodges GJ. Aging and aerobic fitness affect the contribution of noradrenergic sympathetic nerves to the rapid cutaneous vasodilator response to local heating. J Appl Physiol (1985). 2011 May;110(5):1264-70. doi: 10.1152/japplphysiol.01423.2010. Epub 2011 Feb 17. PubMed PMID: 21330615. 12: Lang JA, Holowatz LA, Kenney WL. Tetrahydrobiopterin does not affect end-organ responsiveness to norepinephrine-mediated vasoconstriction in aged skin. Am J Physiol Regul Integr Comp Physiol. 2010 Dec;299(6):R1651-5. doi: 10.1152/ajpregu.00138.2010. Epub 2010 Oct 6. PubMed PMID: 20926766; PubMed Central PMCID: PMC3007192. 13: Shibasaki M, Aoki K, Morimoto K, Johnson JM, Takamata A. Plasma hyperosmolality elevates the internal temperature threshold for active thermoregulatory vasodilation during heat stress in humans. Am J Physiol Regul Integr Comp Physiol. 2009 Dec;297(6):R1706-12. doi: 10.1152/ajpregu.00242.2009. Epub 2009 Oct 7. PubMed PMID: 19812357. 14: Zhang D, Sato T, Gong D, Fu L, Dai S, Xu H, Wu Q, Wang D, Peng Y, Sun Y. Neural reflex hypotension induced by very small dose of hypertonic NaCl solution in rats. Chin J Physiol. 2009 Feb 28;52(1):8-15. PubMed PMID: 19764348. 15: Hodges GJ, Kosiba WA, Zhao K, Johnson JM. The involvement of heating rate and vasoconstrictor nerves in the cutaneous vasodilator response to skin warming. Am J Physiol Heart Circ Physiol. 2009 Jan;296(1):H51-6. doi: 10.1152/ajpheart.00919.2008. Epub 2008 Nov 14. PubMed PMID: 19011042; PubMed Central PMCID: PMC2637777. 16: Simmons GH, Minson CT, Cracowski JL, Halliwill JR. Systemic hypoxia causes cutaneous vasodilation in healthy humans. J Appl Physiol (1985). 2007 Aug;103(2):608-15. Epub 2007 May 17. PubMed PMID: 17510298. 17: Tostes RC, Giachini FR, Carneiro FS, Leite R, Inscho EW, Webb RC. Determination of adenosine effects and adenosine receptors in murine corpus cavernosum. J Pharmacol Exp Ther. 2007 Aug;322(2):678-85. Epub 2007 May 9. PubMed PMID: 17494861. 18: Hodges GJ, Traeger JA 3rd, Tang T, Kosiba WA, Zhao K, Johnson JM. Role of sensory nerves in the cutaneous vasoconstrictor response to local cooling in humans. Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H784-9. Epub 2007 Apr 27. PubMed PMID: 17468334. 19: Cakir B, Kasimay O, Devseren E, Yeğen BC. Leptin inhibits gastric emptying in rats: role of CCK receptors and vagal afferent fibers. Physiol Res. 2007;56(3):315-22. Epub 2006 Jun 22. PubMed PMID: 16792473. 20: Yamazaki F, Sone R. Different vascular responses in glabrous and nonglabrous skin with increasing core temperature during exercise. Eur J Appl Physiol. 2006 Jul;97(5):582-90. Epub 2006 Jun 10. PubMed PMID: 16767440.