Synonym
SC-48274; SC 48274; SC48274;
IUPAC/Chemical Name
3-(3-(dimethylamino)propyl)-3-(3-methoxyphenyl)-4,4-dimethylpiperidine-2,6-dione hydrochloride
InChi Key
WCDCKCAPKMUVHY-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H28N2O3.ClH/c1-18(2)13-16(22)20-17(23)19(18,10-7-11-21(3)4)14-8-6-9-15(12-14)24-5;/h6,8-9,12H,7,10-11,13H2,1-5H3,(H,20,22,23);1H
SMILES Code
O=C(C(C1=CC=CC(OC)=C1)(CCCN(C)C)C(C)(C)C2)NC2=O.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
368.90
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Kawasaki H, Takasaki K. [Electroencephalographic study with SC-48274, a novel nonbenzodiazepine anxiolytic in conscious rabbits]. Nihon Yakurigaku Zasshi. 1991 Oct;98(4):259-72. Japanese. PubMed PMID: 1687040.
2: Ogawa N, Hara C, Takaki S. Anxiolytic activity of SC-48274 compared with those of buspirone and diazepam in experimental anxiety models. Jpn J Pharmacol. 1993 Feb;61(2):115-21. PubMed PMID: 8096257.
3: Gittos MW. The anxiolytic SC 48274 (AGN 2979; BTG 1501) in generalized anxiety disorder. Prog Neuropsychopharmacol Biol Psychiatry. 1994 Jul;18(4):831-2. Corrected and republished in: Prog Neuropsychopharmacol Biol Psychiatry. 1994 Dec;18(8):i-ii. PubMed PMID: 7938570.
4: Gittos MW. The anxiolytic SC 48274 (AGN 2979; BTG 1501) in generalized anxiety disorder. Prog Neuropsychopharmacol Biol Psychiatry. 1994 Dec;18(8):i-ii. PubMed PMID: 7863012.
5: Cutler NR, Sramek JJ, Macpherson AE, Doss MG, Benes CO, Howard SF. An evaluation of the anxiolytic SC 48,274 in generalized anxiety disorder (GAD). Prog Neuropsychopharmacol Biol Psychiatry. 1994 Jul;18(4):685-94. PubMed PMID: 7938559.
6: Gittos MW, Papp M. Antidepressant-like action of AGN 2979, a tryptophan hydroxylase activation inhibitor, in a chronic mild stress model of depression in rats. Eur Neuropsychopharmacol. 2001 Oct;11(5):351-7. PubMed PMID: 11597821.
7: Kanemaru K, Nishi K, Diksic M. AGN-2979, an inhibitor of tryptophan hydroxylase activation, does not affect serotonin synthesis in Flinders Sensitive Line rats, a rat model of depression, but produces a significant effect in Flinders Resistant Line rats. Neurochem Int. 2009 Dec;55(7):529-35. doi: 10.1016/j.neuint.2009.05.008. Epub 2009 May 20. PubMed PMID: 19463878; PubMed Central PMCID: PMC2778282.
8: Boadle-Biber MC, Phan TH. AGN 2979 [3(3-methoxyphenyl)-3-(3-dimethylaminopropyl)-4, 4-dimethylpiperidine-2,6-dione]. An inhibitor of the activation of tryptophan hydroxylase. Biochem Pharmacol. 1986 May 1;35(9):1521-6. PubMed PMID: 3707615.
9: Hasegawa S, Kanemaru K, Gittos M, Diksic M. The tryptophan hydroxylase activation inhibitor, AGN-2979, decreases regional 5-HT synthesis in the rat brain measured with alpha-[14C]methyl-L-tryptophan: an autoradiographic study. Brain Res Bull. 2005 Oct 15;67(3):248-55. PubMed PMID: 16144662.
