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MedKoo Cat#: 461888 | Name: SC 53228

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SC 53228 is a specific leukotriene B4 receptor antagonist.

Chemical Structure

SC 53228
SC 53228
CAS#153633-01-3

Theoretical Analysis

MedKoo Cat#: 461888

Name: SC 53228

CAS#: 153633-01-3

Chemical Formula: C31H41NO7

Exact Mass: 539.2883

Molecular Weight: 539.66

Elemental Analysis: C, 68.99; H, 7.66; N, 2.60; O, 20.75

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SC 53228; SC-53228; SC53228;
IUPAC/Chemical Name
(S)-3-(7-(3-(2-(cyclopropylmethyl)-3-methoxy-4-(methylcarbamoyl)phenoxy)propoxy)-8-propylchroman-2-yl)propanoic acid
InChi Key
YWYUQSGYKDEAMJ-QFIPXVFZSA-N
InChi Code
InChI=1S/C31H41NO7/c1-4-6-23-26(14-10-21-9-11-22(39-29(21)23)12-16-28(33)34)37-17-5-18-38-27-15-13-24(31(35)32-2)30(36-3)25(27)19-20-7-8-20/h10,13-15,20,22H,4-9,11-12,16-19H2,1-3H3,(H,32,35)(H,33,34)/t22-/m0/s1
SMILES Code
O=C(O)CC[C@@H]1CCC2=CC=C(OCCCOC3=CC=C(C(NC)=O)C(OC)=C3CC4CC4)C(CCC)=C2O1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 539.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Stevens WH, Vanderheyden C, Wattie J, Lane CG, Smith W, O'Byrne PM. Effect of a leukotriene B4 receptor antagonist SC-53228 on ozone-induced airway hyperresponsiveness and inflammation in dogs. Am J Respir Crit Care Med. 1995 Nov;152(5 Pt 1):1443-8. PubMed PMID: 7582275. 2: Fretland DJ, Gokhale R, Mathur L, Baron DA, Paulson SK, Stolzenbach J. Dermal inflammation in primates, mice, and guinea pigs: attenuation by second-generation leukotriene B4 receptor antagonist, SC-53228. Inflammation. 1995 Jun;19(3):333-46. PubMed PMID: 7628862. 3: Fretland DJ, Anglin CP, Bremer M, Isakson P, Widomski DL, Paulson SK, Docter SH, Djuric SW, Penning TD, Yu S, et al. Antiinflammatory effects of second-generation leukotriene B4 receptor antagonist, SC-53228: impact upon leukotriene B4- and 12(R)-HETE-mediated events. Inflammation. 1995 Apr;19(2):193-205. PubMed PMID: 7601505. 4: Tsai BS, Keith RH, Villani-Price D, Kachur JF, Yang DC, Djuric SW, Yu S. The in vitro pharmacology of SC-51146: a potent antagonist of leukotriene B4 receptors. J Pharmacol Exp Ther. 1994 Mar;268(3):1499-505. PubMed PMID: 8138960. 5: Fretland DJ, Anglin CP, Widomski D, Baron DA, Maziasz T, Smith PF. Pharmacological activity of the second generation leukotriene B4 receptor antagonist, SC-53228: effects on acute colonic inflammation and hepatic function in rodents. Inflammation. 1995 Oct;19(5):503-15. PubMed PMID: 8543366. 6: Paulson S, Readus Y, Bulik S, Schoenhard G, Stolzenbach J, Fretland D. The pharmacokinetics and metabolism of SC-53228, a specific leukotriene B4 receptor antagonist. Inflamm Res. 1995 Aug;44 Suppl 2:S143-4. PubMed PMID: 8548369. 7: Fretland DJ, Widomski DL, Anglin CP, Penning TD, Yu S, Djuric SW. Leukotriene B4-induced granulocyte trafficking in guinea pig dermis. Effect of second-generation leukotriene B4 receptor antagonists, SC-50605 and SC-51146. Inflammation. 1993 Jun;17(3):353-60. PubMed PMID: 8392493. 8: Rao TS, Yu SS, Djuric SW, Isakson PC. Phorbol ester-induced dermal inflammation in mice: evaluation of inhibitors of 5-lipoxygenase and antagonists of leukotriene B4 receptor. J Lipid Mediat Cell Signal. 1994 Sep;10(3):213-28. PubMed PMID: 7812673. 9: Fretland D, Anglin C, Baron D, Widomski D, Chauhan K, Bhatt R, Falck J. 3(S)-hydroxy-leukotriene B4 is a potent granulocyte chemotaxin in the guinea pig dermis. Inflamm Res. 1995 Aug;44 Suppl 2:S137-8. PubMed PMID: 8548366.

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