Synonym
Bemitradine; SC 33643; SC-33643; SC33643;
IUPAC/Chemical Name
8-(2-ethoxyethyl)-7-phenyl-[1,2,4]triazolo[1,5-c]pyrimidin-5-amine
InChi Key
OZSPQIXKOVJJGE-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H17N5O/c1-2-21-9-8-12-13(11-6-4-3-5-7-11)19-15(16)20-14(12)17-10-18-20/h3-7,10H,2,8-9H2,1H3,(H2,16,19)
SMILES Code
NC1=NC(C2=CC=CC=C2)=C(CCOCC)C3=NC=NN13
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
283.33
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Gad SC, Burton E, Chengelis CP, Levin S, Piper CE, Oshiro Y, Semler DE. Promotional activities of the non-genotoxic carcinogen bemitradine (SC-33643). J Appl Toxicol. 1992 Jun;12(3):157-64. PubMed PMID: 1629511.
2: Walls CM, Gray A, Vose CW, Robinson Y, Lopez N, Brownsill RD, Steiner JA. Disposition of bemitradine, a renal vasodilator and diuretic, in man. Xenobiotica. 1988 Dec;18(12):1413-23. PubMed PMID: 3245233.
3: Oshiro Y, Balwierz PS, Morris DL, Alden CL, Bunch RT. Morphological transformation of Syrian hamster embryo cells at pH 6.7 by bemitradine, a nongenotoxic carcinogen. In Vitr Mol Toxicol. 2001 Summer;14(2):121-7. PubMed PMID: 11690565.
4: Oshiro Y, Piper CE, Garriott ML, Balwierz PS, Soelter SG, Rohrbacher E. Genetic toxicology studies with a tumor promoter. J Appl Toxicol. 1993 Mar-Apr;13(2):91-101. PubMed PMID: 8486916.
5: Kramer JA, Curtiss SW, Kolaja KL, Alden CL, Blomme EA, Curtiss WC, Davila JC, Jackson CJ, Bunch RT. Acute molecular markers of rodent hepatic carcinogenesis identified by transcription profiling. Chem Res Toxicol. 2004 Apr;17(4):463-70. PubMed PMID: 15089088.
