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MedKoo Cat#: 592950 | Name: Arjunolic Acid
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Arjunolic acid is a new multifunctional therapeutic promise of alternative medicine. Arjunolic acid is a natural peroxisome proliferator-activated receptor α agonist which regresses cardiac fibrosis by inhibiting non-canonical TGF-β signaling.

Chemical Structure

Arjunolic Acid
CAS# 465-00-9

Theoretical Analysis

MedKoo Cat#: 592950

Name: Arjunolic Acid

CAS#: 465-00-9

Chemical Formula: C30H48O5

Exact Mass: 488.3502

Molecular Weight: 488.71

Elemental Analysis: C, 73.73; H, 9.90; O, 16.37

Price and Availability

Size Price Availability Quantity
1mg USD 500.00 2 Weeks
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Synonym
Arjunolic acid
IUPAC/Chemical Name
Olean-12-en-28-oic acid, 2,3,23-trihydroxy-, (2alpha,3beta,4alpha)-
InChi Key
RWNHLTKFBKYDOJ-DDHMHSPCSA-N
InChi Code
InChI=1S/C30H48O5/c1-25(2)11-13-30(24(34)35)14-12-28(5)18(19(30)15-25)7-8-22-26(3)16-20(32)23(33)27(4,17-31)21(26)9-10-29(22,28)6/h7,19-23,31-33H,8-17H2,1-6H3,(H,34,35)/t19-,20+,21+,22+,23-,26-,27-,28+,29+,30-/m0/s1
SMILES Code
C[C@@]1(CO)[C@@H](O)[C@H](O)C[C@]2(C)[C@@]3([H])CC=C4[C@]5([H])CC(C)(C)CC[C@@](C(O)=O)5CC[C@](C)4[C@@](C)3CC[C@@]12[H]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 488.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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PubMed PMID: 28821620; PubMed Central PMCID: PMC5633106. 4: Maity M, Perveen H, Dash M, Jana S, Khatun S, Dey A, Mandal AK, Chattopadhyay S. Arjunolic Acid Improves the Serum Level of Vitamin B(12) and Folate in the Process of the Attenuation of Arsenic Induced Uterine Oxidative Stress. Biol Trace Elem Res. 2018 Mar;182(1):78-90. doi: 10.1007/s12011-017-1077-0. Epub 2017 Jun 28. PubMed PMID: 28660490. 5: Bag BG, Majumdar R. Self-assembly of Renewable Nano-sized Triterpenoids. Chem Rec. 2017 Sep;17(9):841-873. doi: 10.1002/tcr.201600123. Epub 2017 Feb 14. Review. PubMed PMID: 28195390. 6: Lin Z, Wu ZF, Jiang CH, Zhang QW, Ouyang S, Che CT, Zhang J, Yin ZQ. The chloroform extract of Cyclocarya paliurus attenuates high-fat diet induced non-alcoholic hepatic steatosis in Sprague Dawley rats. Phytomedicine. 2016 Nov 15;23(12):1475-1483. doi: 10.1016/j.phymed.2016.08.003. Epub 2016 Aug 17. PubMed PMID: 27765368. 7: Zebiri I, Haddad M, Duca L, Sauvain M, Paloque L, Cabanillas B, Rengifo E, Behr JB, Voutquenne-Nazabadioko L. Biological activities of triterpenoids from Poraqueiba sericea stems. Nat Prod Res. 2017 Jun;31(11):1333-1338. doi: 10.1080/14786419.2016.1241998. Epub 2016 Oct 13. PubMed PMID: 27736194. 8: Majumdar R, Tantayanon S, Gopal Bag B. A Novel Trihybrid Material Based on Renewables: An Efficient Recyclable Heterogeneous Catalyst for C-C Coupling and Reduction Reactions. Chem Asian J. 2016 Sep 6;11(17):2406-14. doi: 10.1002/asia.201600773. Epub 2016 Aug 11. PubMed PMID: 27511441. 9: Elsherbiny NM, Al-Gayyar MM. Anti-tumor activity of arjunolic acid against Ehrlich Ascites Carcinoma cells in vivo and in vitro through blocking TGF-β type 1 receptor. Biomed Pharmacother. 2016 Aug;82:28-34. doi: 10.1016/j.biopha.2016.04.046. Epub 2016 May 3. PubMed PMID: 27470335. 10: Pandit S, Kanjilal S, Awasthi A, Chaudhary A, Banerjee D, Bhatt BN, Narwaria A, Singh R, Dutta K, Jaggi M, Singh AT, Sharma N, Katiyar CK. Evaluation of herb-drug interaction of a polyherbal Ayurvedic formulation through high throughput cytochrome P450 enzyme inhibition assay. J Ethnopharmacol. 2017 Feb 2;197:165-172. doi: 10.1016/j.jep.2016.07.061. Epub 2016 Jul 25. PubMed PMID: 27457692. 11: Lu HX, Wu ZL, Liang WJ, Chen ML, Huang BB, Wei QQ. [Chemical Constituents from Semiliquidambar cathayensis Roots]. Zhong Yao Cai. 2015 Dec;38(12):2543-6. Chinese. PubMed PMID: 27352536. 12: Uzor PF, Osadebe PO. Antidiabetic activity of the chemical constituents of Combretum dolichopetalum root in mice. EXCLI J. 2016 Apr 25;15:290-6. doi: 10.17179/excli2016-252. eCollection 2016. PubMed PMID: 27298614; PubMed Central PMCID: PMC4897660. 13: Kalyanavenkataraman S, Nanjan P, Banerji A, Nair BG, Kumar GB. Discovery of arjunolic acid as a novel non-zinc binding carbonic anhydrase II inhibitor. Bioorg Chem. 2016 Jun;66:72-9. doi: 10.1016/j.bioorg.2016.03.009. Epub 2016 Mar 24. PubMed PMID: 27038848. 14: Guldbrandsen N, De Mieri M, Gupta M, Seiser T, Wiebe C, Dickhaut J, Reingruber R, Sorgenfrei O, Hamburger M. Screening of Panamanian Plant Extracts for Pesticidal Properties and HPLC-Based Identification of Active Compounds. Sci Pharm. 2014 Dec 11;83(2):353-67. doi: 10.3797/scipharm.1410-10. Print 2015 Apr-Jun. PubMed PMID: 26839818; PubMed Central PMCID: PMC4729439. 15: Lacouth-Silva F, Xavier CV, da S Setúbal S, Pontes AS, Nery NM, de Castro OB, Fernandes CF, Honda ER, Zanchi FB, Calderon LA, Stábeli RG, Soares AM, Silva-Jardim I, Facundo VA, Zuliani JP. The effect of 3β, 6β, 16β-trihydroxylup-20(29)-ene lupane compound isolated from Combretum leprosum Mart. on peripheral blood mononuclear cells. BMC Complement Altern Med. 2015 Nov 25;15(1):420. doi: 10.1186/s12906-015-0948-1. PubMed PMID: 26608735; PubMed Central PMCID: PMC4659216. 16: Alyoussef A. Arjunolic acid protects against DNCB-induced atopic dermatitis-like symptoms in mice by restoring a normal cytokine balance. Eur Cytokine Netw. 2015 Apr-Jun;26(2):38-45. doi: 10.1684/ecn.2015.0364. PubMed PMID: 26553587. 17: Elsherbiny NM, Eladl MA, Al-Gayyar MM. Renal protective effects of arjunolic acid in a cisplatin-induced nephrotoxicity model. Cytokine. 2016 Jan;77:26-34. doi: 10.1016/j.cyto.2015.10.010. Epub 2015 Oct 27. PubMed PMID: 26517155. 18: Jiang C, Wang Q, Wei Y, Yao N, Wu Z, Ma Y, Lin Z, Zhao M, Che C, Yao X, Zhang J, Yin Z. Cholesterol-lowering effects and potential mechanisms of different polar extracts from Cyclocarya paliurus leave in hyperlipidemic mice. J Ethnopharmacol. 2015 Dec 24;176:17-26. doi: 10.1016/j.jep.2015.10.006. Epub 2015 Oct 23. PubMed PMID: 26477373. 19: Sun J, Huo HX, Huang Z, Zhang J, Li J, Tu PF. A new γ-alkylated-γ-butyrolactone from the roots of Solanum melongena. Chin J Nat Med. 2015 Sep;13(9):699-703. doi: 10.1016/S1875-5364(15)30068-6. PubMed PMID: 26412430. 20: Yaidikar L, Thakur S. Arjunolic acid, a pentacyclic triterpenoidal saponin of Terminalia arjuna bark protects neurons from oxidative stress associated damage in focal cerebral ischemia and reperfusion. Pharmacol Rep. 2015 Oct;67(5):890-5. doi: 10.1016/j.pharep.2015.02.003. Epub 2015 Feb 19. PubMed PMID: 26398381.