Synonym
Ganhuangenin; Sb 1; Sb-1; Sb1;
IUPAC/Chemical Name
2-(3,6-dihydroxy-2-methoxyphenyl)-5,7-dihydroxy-8-methoxy-4H-chromen-4-one
InChi Key
CPFJPTACQDZPLS-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H14O8/c1-23-15-8(19)4-3-7(18)14(15)12-6-10(21)13-9(20)5-11(22)16(24-2)17(13)25-12/h3-6,18-20,22H,1-2H3
SMILES Code
O=C1C=C(C2=C(O)C=CC(O)=C2OC)OC3=C(OC)C(O)=CC(O)=C13
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
346.29
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Lim BO, Yu BP, Kim SC, Park DK. The antioxidative effect of ganhuangenin against lipid peroxidation. Phytother Res. 1999 Sep;13(6):479-83. PubMed PMID: 10479757.
2: Lim BO. Effect of ganhuangenin obtained from Scutellaria radix on the chemical mediator production of peritoneal exudate cells and immunoglobulin E level of mesenteric lymph node lymphocytes in Sprague-Dawley rats. Phytother Res. 2002 Mar;16(2):166-70. PubMed PMID: 11933121.
3: Liu YL, Song WZ, Ji QY, Bai YL. [The structure of ganhuangenin, a new flavonoid from the root of gansuhuangqin (Scutellaria rehderiana)]. Yao Xue Xue Bao. 1984 Nov;19(11):830-5. Chinese. PubMed PMID: 6544550.
4: Liu Z, Wu J, Huang D. New stilbenoids isolated from fungus-challenged black skin peanut seeds and their adipogenesis inhibitory activity in 3T3-L1 cells. J Agric Food Chem. 2013 May 1;61(17):4155-61. doi: 10.1021/jf400144s. Epub 2013 Apr 17. PubMed PMID: 23560846.
5: Tsai PJ, Huang WC, Hsieh MC, Sung PJ, Kuo YH, Wu WH. Flavones Isolated from Scutellariae radix Suppress Propionibacterium Acnes-Induced Cytokine Production In Vitro and In Vivo. Molecules. 2015 Dec 24;21(1):E15. doi: 10.3390/molecules21010015. PubMed PMID: 26712724.
6: Su YL, Huang Y, Chen ZY. [Isolation and elucidation of antioxidant constituents from acetone extract in root of Scutellaria rehderiana]. Zhongguo Zhong Yao Za Zhi. 2004 Sep;29(9):863-4. Chinese. PubMed PMID: 15575204.
7: BERINGER A. [The therapy of diabetes mellitus with SB 1]. Wien Med Wochenschr. 1960 Feb 13;110:109-11. German. PubMed PMID: 13799474.
8: REGAMEY RH. [Study on the absence of antibacterial properties in a new synthetic antidiabetic, 1-(3-aminobenzenesulfonyl)-3-n-butylurea or SB 1]. Schweiz Med Wochenschr. 1959 Nov 7;89:1183-6. French. PubMed PMID: 14436950.
9: Kimura Y, Okuda H, Taira Z, Shoji N, Takemoto T, Arichi S. Studies on Scutellariae radix. IX. New component inhibiting lipid peroxidation in rat liver. Planta Med. 1984 Aug;50(4):290-5. PubMed PMID: 6548821.
10: BICKEL G, KORALNIK O. [First clinical trials of a new synthetic antidiabetic SB 1 or 1-(3-aminobenzenesulfonyl)-3-n-butylurea]. Schweiz Med Wochenschr. 1959 Nov 7;89:1186-91. French. PubMed PMID: 13800475.
11: Lim BO, Choue RW, Lee HY, Seong NS, Kim JD. Effect of the flavonoid components obtained from Scutellaria radix on the histamine, immunoglobulin E and lipid peroxidation of spleen lymphocytes of Sprague-Dawley rats. Biosci Biotechnol Biochem. 2003 May;67(5):1126-9. PubMed PMID: 12834292.
