Synonym
Perfluidone; Destun; SB 1528; SB-1528; SB1528; WL 43423; WL-43423; WL43423;
IUPAC/Chemical Name
1,1,1-trifluoro-N-(2-methyl-4-(phenylsulfonyl)phenyl)methanesulfonamide
InChi Key
WHTBVLXUSXVMEV-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H12F3NO4S2/c1-10-9-12(23(19,20)11-5-3-2-4-6-11)7-8-13(10)18-24(21,22)14(15,16)17/h2-9,18H,1H3
SMILES Code
O=S(C(F)(F)F)(NC1=CC=C(S(=O)(C2=CC=CC=C2)=O)C=C1C)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
379.36
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Tresch S, Heilmann M, Christiansen N, Looser R, Grossmann K. Inhibition of saturated very-long-chain fatty acid biosynthesis by mefluidide and perfluidone, selective inhibitors of 3-ketoacyl-CoA synthases. Phytochemistry. 2012 Apr;76:162-71. doi: 10.1016/j.phytochem.2011.12.023. Epub 2012 Jan 25. PubMed PMID: 22284369.
2: Olorunsogo OO, Malomo SO. Mitochondrial bioenergetics during exposure of rats to perfluidone, a fluorinated arylalkylsulphonamide. Chem Biol Interact. 1984 Nov;52(1):67-78. PubMed PMID: 6238687.
3: Olorunsogo OO, Malomo SO. Sensitivity of oligomycin-inhibited respiration of isolated rat liver mitochondria to perfluidone, a fluorinated arylalkylsulfonamide. Toxicology. 1985 Jun 14;35(3):231-40. PubMed PMID: 3160138.
4: Olorunsogo OO, Malomo SO, Bababunmi EA. Protonophoric properties of fluorinated arylalkylsulfonamides. Observations with perfluidone. Biochem Pharmacol. 1985 Aug 15;34(16):2945-52. PubMed PMID: 2992524.
5: Olorunsogo OO, Malomo SO, Bababunmi EA. Perfluidone, a fluorinated arylalkylsulphonamide carries protons across mitochondrial coupling membrane. Dev Toxicol Environ Sci. 1983;11:345-8. PubMed PMID: 6677469.
6: Ivie GW. Metabolic fate of perfluidone herbicide in a lactating cow. J Agric Food Chem. 1975 Sep-Oct;23(5):869-72. PubMed PMID: 1171900.
7: Tafuri F, Businelli M, Scarponi L, Marucchini C. Stimulation of the activity of the IAA-oxidising enzyme system in Lens culinaris roots by dalapon and perfluidone. J Sci Food Agric. 1977 Feb;28(2):180-4. PubMed PMID: 853723.
8: Horowitz M. Herbicidal treatments for control of Papaver somniferum L. Bull Narc. 1980;32(1):33-43. PubMed PMID: 6905769.
9: Thabrew MI, Emerole GO. Species variations in the sensitivity of the endoplasmic reticulum to the herbicide 1.1.1. trifluoro-N-(2-methyl-4-phenyl sulfonyl phenyl) methane sulfonamide. Comp Biochem Physiol C. 1983;74(2):473-6. PubMed PMID: 6133695.
10: Thabrew MI, Emerole GO. Effect of 1.1.1 trifluoro-N-(2-methyl-4-phenyl sulfonyl) methane sulfonamide (Destun 50WP) on rat hepatic microsomal enzymes, aniline hydroxylase and amino-pyrine N-demethylase. Eur J Drug Metab Pharmacokinet. 1983 Oct-Dec;8(4):321-7. PubMed PMID: 6673969.
