MedKoo Cat#: 592940 | Name: Argiprestocin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Argiprestocin is a nonapeptide that contains the ring of OXYTOCIN and the side chain of ARG-VASOPRESSIN with the latter determining the specific recognition of hormone receptors. Vasotocin is the non-mammalian vasopressin-like hormone or antidiuretic hormone regulating water and salt metabolism.

Chemical Structure

Argiprestocin
CAS#113-80-4

Theoretical Analysis

MedKoo Cat#: 592940

Name: Argiprestocin

CAS#: 113-80-4

Chemical Formula: C43H67N15O12S2

Exact Mass: 1049.4535

Molecular Weight: 1050.22

Elemental Analysis: C, 49.18; H, 6.43; N, 20.01; O, 18.28; S, 6.11

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Argiprestocin
IUPAC/Chemical Name
8-Arginineoxytocin
InChi Key
OXDZADMCOWPSOC-BQGUCLBMSA-N
InChi Code
InChI=1S/C43H67N15O12S2/c1-3-21(2)34-41(69)53-26(12-13-31(45)60)37(65)55-28(17-32(46)61)38(66)56-29(20-72-71-19-24(44)35(63)54-27(39(67)57-34)16-22-8-10-23(59)11-9-22)42(70)58-15-5-7-30(58)40(68)52-25(6-4-14-50-43(48)49)36(64)51-18-33(47)62/h8-11,21,24-30,34,59H,3-7,12-20,44H2,1-2H3,(H2,45,60)(H2,46,61)(H2,47,62)(H,51,64)(H,52,68)(H,53,69)(H,54,63)(H,55,65)(H,56,66)(H,57,67)(H4,48,49,50)/t21-,24-,25-,26-,27-,28-,29-,30-,34-/m0/s1
SMILES Code
CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CCC(=O)N)NC1=O)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,050.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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[Epub ahead of print] PubMed PMID: 29964006. 4: Liutkevičiūtė Z, Gil-Mansilla E, Eder T, Casillas-Pérez B, Di Giglio MG, Muratspahić E, Grebien F, Rattei T, Muttenthaler M, Cremer S, Gruber CW. Oxytocin-like signaling in ants influences metabolic gene expression and locomotor activity. FASEB J. 2018 Jun 25:fj201800443. doi: 10.1096/fj.201800443. [Epub ahead of print] PubMed PMID: 29939785. 5: DeAngelis R, Dodd L, Snyder A, Rhodes JS. Dynamic regulation of brain aromatase and isotocin receptor gene expression depends on parenting status. Horm Behav. 2018 Jul;103:62-70. doi: 10.1016/j.yhbeh.2018.06.006. Epub 2018 Jun 22. PubMed PMID: 29928890. 6: Nakano M, Hasunuma I, Minagawa A, Iwamuro S, Yamamoto K, Kikuyama S, Machida T, Kobayashi T. Possible involvement of thyrotropin-releasing hormone receptor 3 in the release of prolactin in the metamorphosing bullfrog larvae. Gen Comp Endocrinol. 2018 Jun 2. pii: S0016-6480(18)30065-0. doi: 10.1016/j.ygcen.2018.05.029. [Epub ahead of print] PubMed PMID: 29864416. 7: Srivastava R, Cornett LE, Chaturvedi CM. Impact of estrogen and photoperiod on arginine vasotocin and VT3 receptor expression in the shell gland of quail. Front Biosci (Schol Ed). 2018 Jun 1;10:372-385. PubMed PMID: 29772564. 8: Silva AC, Pandolfi M. Vasotocinergic control of agonistic behavior told by Neotropical fishes. Gen Comp Endocrinol. 2018 Apr 24. pii: S0016-6480(17)30879-1. doi: 10.1016/j.ygcen.2018.04.025. [Epub ahead of print] Review. PubMed PMID: 29702104. 9: Loveland JL, Hu CK. Corrigendum: Commentary: Arginine Vasotocin Preprohormone Is Expressed in Surprising Regions of the Teleost Forebrain. Front Endocrinol (Lausanne). 2018 Apr 6;9:157. doi: 10.3389/fendo.2018.00157. eCollection 2018. PubMed PMID: 29676406; PubMed Central PMCID: PMC5904497. 10: Kang SW, Jayanthi S, Nagarajan G, Suresh Kumar TK, Kuenzel WJ. Identification of avian vasotocin receptor subtype-specific antagonists involved in the stress response of the chicken, Gallus gallus. J Biomol Struct Dyn. 2018 May 17:1-15. doi: 10.1080/07391102.2018.1464957. [Epub ahead of print] PubMed PMID: 29658387. 11: Guy J, O'Kane E, Eggleton A. Steroids, atosiban and pulmonary oedema: are or may be a cause? Int J Obstet Anesth. 2018 May;34:115. doi: 10.1016/j.ijoa.2018.03.004. Epub 2018 Mar 15. PubMed PMID: 29602690. 12: Loveland JL, Hu CK. Commentary: Arginine Vasotocin Preprohormone Is Expressed in Surprising Regions of the Teleost Forebrain. Front Endocrinol (Lausanne). 2018 Mar 1;9:63. doi: 10.3389/fendo.2018.00063. eCollection 2018. Erratum in: Front Endocrinol (Lausanne). 2018 Apr 06;9:157. PubMed PMID: 29545774; PubMed Central PMCID: PMC5838006. 13: Nijs K, Nulens K, Dubois J, Van de Velde M, Stessel B. In reply: steroids, atosiban and pulmonary oedema; are or may be a cause? Int J Obstet Anesth. 2018 May;34:115-116. doi: 10.1016/j.ijoa.2018.02.006. Epub 2018 Feb 20. PubMed PMID: 29534949. 14: Skrzynska AK, Maiorano E, Bastaroli M, Naderi F, Míguez JM, Martínez-Rodríguez G, Mancera JM, Martos-Sitcha JA. Impact of Air Exposure on Vasotocinergic and Isotocinergic Systems in Gilthead Sea Bream (Sparus aurata): New Insights on Fish Stress Response. Front Physiol. 2018 Feb 13;9:96. doi: 10.3389/fphys.2018.00096. eCollection 2018. PubMed PMID: 29487539; PubMed Central PMCID: PMC5816901. 15: Bouchekioua S, Hur SP, Takeuchi Y, Lee YD, Takemura A. Effects of temperature and melatonin on day-night expression patterns of arginine vasotocin and isotocin mRNA in the diencephalon of a temperate wrasse Halichoeres tenuispinis. Fish Physiol Biochem. 2018 Jun;44(3):817-828. doi: 10.1007/s10695-018-0471-7. Epub 2018 Feb 5. PubMed PMID: 29404822. 16: Perrone R, Silva AC. Status-Dependent Vasotocin Modulation of Dominance and Subordination in the Weakly Electric Fish Gymnotus omarorum. Front Behav Neurosci. 2018 Jan 18;12:1. doi: 10.3389/fnbeh.2018.00001. eCollection 2018. PubMed PMID: 29403366; PubMed Central PMCID: PMC5778121. 17: Lind CM, Ramis F, Paredes DG, Moore IT, Vernasco BJ, Farrell TM. Mechanisms underlying maternal care in a viviparous snake, Sistrurus miliarius: Does maternal body condition, corticosterone, or arginine vasotocin mediate post-birth maternal investment? J Exp Zool A Ecol Integr Physiol. 2017 Aug;327(7):458-465. doi: 10.1002/jez.2132. Epub 2017 Dec 4. PubMed PMID: 29356456. 18: Acharjee A, Chaube R, Joy KP. Reproductive stage- and sex-dependant effects of neurohypophyseal nonapeptides on gonadotropin subunit mRNA expression in the catfish Heteropneustes fossilis: An in vitro study. Gen Comp Endocrinol. 2018 May 1;260:80-89. doi: 10.1016/j.ygcen.2018.01.001. Epub 2018 Jan 3. PubMed PMID: 29305879. 19: Backström T, Winberg S. Serotonin Coordinates Responses to Social Stress-What We Can Learn from Fish. Front Neurosci. 2017 Oct 25;11:595. doi: 10.3389/fnins.2017.00595. eCollection 2017. Review. PubMed PMID: 29163002; PubMed Central PMCID: PMC5669303. 20: Kocyigit UM, Taşkıran AŞ, Taslimi P, Yokuş A, Temel Y, Gulçin İ. Inhibitory effects of oxytocin and oxytocin receptor antagonist atosiban on the activities of carbonic anhydrase and acetylcholinesterase enzymes in the liver and kidney tissues of rats. J Biochem Mol Toxicol. 2017 Nov;31(11). doi: 10.1002/jbt.21972. Epub 2017 Aug 16. PubMed PMID: 29116677.