MedKoo Cat#: 461844 | Name: Sauristolactam

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sauristolactam is a natural aristolactam.

Chemical Structure

Sauristolactam
Sauristolactam
CAS#128533-02-8

Theoretical Analysis

MedKoo Cat#: 461844

Name: Sauristolactam

CAS#: 128533-02-8

Chemical Formula: C17H13NO3

Exact Mass: 279.0895

Molecular Weight: 279.29

Elemental Analysis: C, 73.11; H, 4.69; N, 5.02; O, 17.19

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Sauristolactam;
IUPAC/Chemical Name
2-hydroxy-1-methoxy-5-methyldibenzo[cd,f]indol-4(5H)-one
InChi Key
WRFZNTLPRUIGKH-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H13NO3/c1-18-12-7-9-5-3-4-6-10(9)15-14(12)11(17(18)20)8-13(19)16(15)21-2/h3-8,19H,1-2H3
SMILES Code
O=C1N(C)C2=C3C1=CC(O)=C(OC)C3=C4C(C=CC=C4)=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 279.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Levrier C, Balastrier M, Beattie KD, Carroll AR, Martin F, Choomuenwai V, Davis RA. Pyridocoumarin, aristolactam and aporphine alkaloids from the Australian rainforest plant Goniothalamus australis. Phytochemistry. 2013 Feb;86:121-6. doi: 10.1016/j.phytochem.2012.09.019. Epub 2012 Nov 16. PubMed PMID: 23158725. 2: Rao KV, Reddy GC. Chemistry of Saururus cernuus, V. sauristolactam and other nitrogenous constituents. J Nat Prod. 1990 Mar-Apr;53(2):309-12. PubMed PMID: 2380708. 3: Leem DH, Choi KH, Han HS, Kim JH, Shin JA, Choi ES, Shim JH, Kong G, Min YK, Nam JS, Oh SH, Kim KA, Kwon KH, Cho NP, Cho SD. KO-202125, a sauristolactam derivate, induces apoptosis to prevent KB human oral squamous carcinoma cells through inhibition of cyclooxygenase-2 expression. Eur J Cancer Prev. 2010 Jan;19(1):23-30. doi: 10.1097/CEJ.0b013e328333d09e. PubMed PMID: 19910795. 4: Kim JK, Kim YH, Nam HT, Kim BT, Heo JN. Total synthesis of aristolactams via a one-pot suzuki-miyaura coupling/aldol condensation cascade reaction. Org Lett. 2008 Aug 21;10(16):3543-6. doi: 10.1021/ol801291k. Epub 2008 Jul 19. PubMed PMID: 18642834. 5: Oh M, Lee JY, Shin DH, Park JH, Oian T, Kim HJ, Cho SD, Oh SH, Min YK, Kong G. The in vitro and in vivo anti-tumor effect of KO-202125, a sauristolactam derivative, as a novel epidermal growth factor receptor inhibitor in human breast cancer. Cancer Sci. 2011 Mar;102(3):597-604. doi: 10.1111/j.1349-7006.2010.01817.x. Epub 2011 Jan 10. PubMed PMID: 21205071. 6: Choi YL, Kim JK, Choi SU, Min YK, Bae MA, Kim BT, Heo JN. Synthesis of aristolactam analogues and evaluation of their antitumor activity. Bioorg Med Chem Lett. 2009 Jun 1;19(11):3036-40. doi: 10.1016/j.bmcl.2009.04.020. Epub 2009 Apr 10. PubMed PMID: 19394218. 7: Sack U, Heinze TM, Deck J, Cerniglia CE, Cazau MC, Fritsche W. Novel metabolites in phenanthrene and pyrene transformation by Aspergillus niger. Appl Environ Microbiol. 1997 Jul;63(7):2906-9. PubMed PMID: 9212437; PubMed Central PMCID: PMC168586. 8: Chen HJ, Li X, Chen JW, Guo S, Cai BC. Simultaneous determination of eleven bioactive compounds in Saururus chinensis from different harvesting seasons by HPLC-DAD. J Pharm Biomed Anal. 2010 Apr 6;51(5):1142-6. doi: 10.1016/j.jpba.2009.11.004. Epub 2009 Nov 13. PubMed PMID: 20004543. 9: Ma L, Wu F, Chen RY. [Advance of chemical constituents and bioactivity of Saururuaceae plants]. Zhongguo Zhong Yao Za Zhi. 2003 Mar;28(3):196-8. Review. Chinese. PubMed PMID: 15015297. 10: Ma Q, Wei R, Wang Z, Liu W, Sang Z, Li Y, Huang H. Bioactive alkaloids from the aerial parts of Houttuynia cordata. J Ethnopharmacol. 2017 Jan 4;195:166-172. doi: 10.1016/j.jep.2016.11.013. Epub 2016 Nov 11. PubMed PMID: 27840258. 11: Chen H, Liu J, Cui M, Chen J, Li X, Chen Y. Simultaneous determination of four amides in Saururus chinensis by matrix solid phase dispersion and high-performance liquid chromatography method. J Food Drug Anal. 2018 Jan;26(1):362-368. doi: 10.1016/j.jfda.2017.03.008. Epub 2017 Apr 19. PubMed PMID: 29389575.