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MedKoo Cat#: 592933 | Name: Trapidil
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Trapidil is a coronary vasodilator agent.

Chemical Structure

Trapidil
Trapidil
CAS#15421-84-8

Theoretical Analysis

MedKoo Cat#: 592933

Name: Trapidil

CAS#: 15421-84-8

Chemical Formula: C10H15N5

Exact Mass: 205.1327

Molecular Weight: 205.27

Elemental Analysis: C, 58.51; H, 7.37; N, 34.12

Price and Availability

Size Price Availability Quantity
10mg USD 290.00
50mg USD 750.00 2 Weeks
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Related CAS #
No Data
Synonym
Trapidil; AR 12008; AR-12008; AR12008
IUPAC/Chemical Name
(1,2,4)Triazolo(1,5-a)pyrimidin-7-amine, N,N-diethyl-5-methyl-
InChi Key
GSNOZLZNQMLSKJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H15N5/c1-4-14(5-2)9-6-8(3)13-10-11-7-12-15(9)10/h6-7H,4-5H2,1-3H3
SMILES Code
CC1=NC2=NC=NN2C(N(CC)CC)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 205.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Liu M, Sun Q, Wang Q, Wang X, Lin P, Yang M, Yan Y. Effect of trapidil in myocardial ischemia-reperfusion injury in rabbit. Indian J Pharmacol. 2014 Mar-Apr;46(2):207-10. doi: 10.4103/0253-7613.129320. PubMed PMID: 24741195; PubMed Central PMCID: PMC3987192. 2: Kim SD, Kim HN, Lee JH, Jin WJ, Hwang SJ, Kim HH, Ha H, Lee ZH. Trapidil, a platelet-derived growth factor antagonist, inhibits osteoclastogenesis by down-regulating NFATc1 and suppresses bone loss in mice. Biochem Pharmacol. 2013 Sep 15;86(6):782-90. doi: 10.1016/j.bcp.2013.07.015. Epub 2013 Aug 6. PubMed PMID: 23928189. 3: Ertan E, Göçer P, Naycı A, Cömelekoğlu U, Atış S, Bozdağan Arpacı R, Ersöz G, Körlü S, Umit Talas D. The effect of trapidil and bevacizumab on tracheal anastomotic wound healing. Curr Ther Res Clin Exp. 2013 Dec;75:5-7. doi: 10.1016/j.curtheres.2013.04.002. PubMed PMID: 24465035; PubMed Central PMCID: PMC3898184. 4: Watanabe I, Okumura Y, Nagashima K, Kofune M, Ohkubo K, Mano H, Sonoda K, Kasamaki Y, Hirayama A. Effects of the antianginal drug trapidil on atrioventricular conduction disturbances during acute myocardial ischemia. Int Heart J. 2012;53(3):187-92. PubMed PMID: 22790688. 5: Salem NA, Salem EA, Maarouf AM, Kamel M, Elgalaly H, Radwan M, El-Dayem WA, Eladl M. Protective effect of trapidil and l-arginine against renal and hepatic toxicity induced by cyclosporine in rats. Ren Fail. 2010;32(8):959-68. doi: 10.3109/0886022X.2010.501933. PubMed PMID: 20722564. 6: Thürmann PA, Harder S, Wolter K, Münck AC, Fritschka E. Pharmacokinetics of the PDGF-antagonist trapidil in patients with and without renal impairment. Clin Nephrol. 1997 Feb;47(2):99-105. PubMed PMID: 9049457. 7: Maresta A, Balducelli M, Cantini L, Casari A, Chioin R, Fabbri M, Fontanelli A, Monici Preti PA, Repetto S, De Servi S, et al. Trapidil (triazolopyrimidine), a platelet-derived growth factor antagonist, reduces restenosis after percutaneous transluminal coronary angioplasty. Results of the randomized, double-blind STARC study. Studio Trapidil versus Aspirin nella Restenosi Coronarica. Circulation. 1994 Dec;90(6):2710-5. PubMed PMID: 7994812. 8: Bozlu M, Acar D, Cayan S, Aktas S, Tunckiran A. Protective effect of trapidil on long-term histologic damage in a rat model of testicular ischemia-reperfusion injury. World J Urol. 2009 Feb;27(1):117-22. doi: 10.1007/s00345-008-0323-7. Epub 2008 Sep 2. PubMed PMID: 18762946. 9: Todo T, Adams EF, Fahlbusch R. Inhibitory effect of trapidil on human meningioma cell proliferation via interruption of autocrine growth stimulation. J Neurosurg. 1993 Mar;78(3):463-9. PubMed PMID: 8433150. 10: Raubach KH, Vlahov V, Wolter K, Bussmann WD. Double-blind randomized multicenter study on the efficacy of trapidil versus isosorbide dinitrate in stable angina pectoris. Clin Cardiol. 1997 May;20(5):483-8. PubMed PMID: 9134282. 11: Tohjima T, Arisaka T, Honda N. In vitro effects of trapidil on fatty acid and prostaglandin metabolism in platelets. Clin Ther. 1994 May-Jun;16(3):405-15. PubMed PMID: 7923307. 12: Berndt A, Looby M, Pönicke K, Zipprich B, Weiss M. Pharmacokinetics of trapidil in patients with chronic liver disease. J Clin Pharmacol. 1996 Oct;36(10):897-902. PubMed PMID: 8930776. 13: Okamoto S, Inden M, Setsuda M, Konishi T, Nakano T. Effects of trapidil (triazolopyrimidine), a platelet-derived growth factor antagonist, in preventing restenosis after percutaneous transluminal coronary angioplasty. Am Heart J. 1992 Jun;123(6):1439-44. PubMed PMID: 1595521. 14: Sziegoleit W, Dannenberg K, Konschak A, Lautenschläger C, Presek P. Influence of systemically given placebo, trapidil and isosorbide dinitrate on norepinephrine-evoked hand vein constriction in healthy subjects. Arzneimittelforschung. 2007;57(2):81-6. PubMed PMID: 17396617. 15: Meinertz T, Lehmacher W; Trapidil/ISDN Study Group. Trapidil is as effective as isosorbide-dinitrate for treating stable angina pectoris: a multinational, multicenter, double-blind, randomized study. Clin Res Cardiol. 2006 Apr;95(4):217-23. Epub 2006 Mar 22. PubMed PMID: 16598591. 16: Atici A, Bozlu G, Turhan AH, Polat A, Nayci A, Okuyaz C, Taskinlar H. The role of trapidil on neuronal apoptosis in neonatal rat model of hypoxic ischemic brain injury. Early Hum Dev. 2008 Apr;84(4):243-7. Epub 2007 Aug 13. PubMed PMID: 17693042. 17: McKay JS, Blakemore WF, Franklin RJ. The effects of the growth factor-antagonist, trapidil, on remyelination in the CNS. Neuropathol Appl Neurobiol. 1997 Feb;23(1):50-8. PubMed PMID: 9061690. 18: Nieder J, Claus P, Augustin W. [Effect of trapidil in prevention of pre-eclampsia and fetal retardation]. Zentralbl Gynakol. 1995;117(1):23-8. German. PubMed PMID: 7879457. 19: Hoshiya M, Awazu M. Trapidil inhibits platelet-derived growth factor-stimulated mitogen-activated protein kinase cascade. Hypertension. 1998 Feb;31(2):665-71. PubMed PMID: 9461238. 20: Zehl U, Mest HJ, Förster W. Influence of aspirin, molsidomine, trapidil, and some trapidil derivatives on arachidonic acid induced reversible thrombocyte aggregation in the rabbit. Biomed Biochim Acta. 1984;43(8-9):S381-4. PubMed PMID: 6440554.