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MedKoo Cat#: 461834 | Name: Aspafilioside B

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Aspafilioside B is a steroidal saponin extracted from Asparagus filicinus that inhibits the growth and proliferation of HCC cell lines.

Chemical Structure

Aspafilioside B
Aspafilioside B
CAS#131123-73-4

Theoretical Analysis

MedKoo Cat#: 461834

Name: Aspafilioside B

CAS#: 131123-73-4

Chemical Formula: C43H70O15

Exact Mass: 826.4715

Molecular Weight: 827.01

Elemental Analysis: C, 62.45; H, 8.53; O, 29.02

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Aspafilioside B;
IUPAC/Chemical Name
(2S,3R,4S,5R)-2-(((2R,3R,4R,6R)-4-hydroxy-6-(((2aR,4S,5'S,6aS,6bS,8aS,8bR,9S,10R,11aS,12aS,12bR)-5',6a,8a,9-tetramethyldocosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-yl)oxy)-2-((((2S,3R,4S,5S)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-3-yl)oxy)tetrahydro-2H-pyran-3,4,5-triol
InChi Key
LGUTXUSCHKEEJA-BFTDEGHSSA-N
InChi Code
InChI=1S/C43H70O15/c1-20-7-12-43(54-16-20)21(2)33-30(58-43)14-26-24-6-5-22-13-23(8-10-41(22,3)25(24)9-11-42(26,33)4)55-32-15-27(44)38(57-40-37(50)35(48)29(46)18-52-40)31(56-32)19-53-39-36(49)34(47)28(45)17-51-39/h20-40,44-50H,5-19H2,1-4H3/t20-,21-,22+,23-,24+,25-,26-,27+,28-,29+,30-,31+,32+,33-,34-,35-,36+,37+,38+,39-,40-,41-,42-,43+/m0/s1
SMILES Code
C[C@H]1CC[C@]2(OC1)[C@@H](C)[C@H]3[C@H](C[C@@H]4[C@]3(C)CC[C@H]5[C@H]4CC[C@H]6[C@]5(C)CC[C@H](O[C@H]7C[C@@H](O)[C@@H](O[C@H]8[C@H](O)[C@@H](O)[C@H](O)CO8)[C@@H](CO[C@H]9[C@H](O)[C@@H](O)[C@@H](O)CO9)O7)C6)O2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 827.01 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Liu W, Ning R, Chen RN, Huang XF, Dai QS, Hu JH, Wang YW, Wu LL, Xiong J, Hu G, Guo QL, Yang J, Wang H. Aspafilioside B induces G2/M cell cycle arrest and apoptosis by up-regulating H-Ras and N-Ras via ERK and p38 MAPK signaling pathways in human hepatoma HepG2 cells. Mol Carcinog. 2016 May;55(5):440-57. doi: 10.1002/mc.22293. Epub 2015 Feb 14. PubMed PMID: 25683703. 2: Wu JJ, Cheng KW, Zuo XF, Wang MF, Li P, Zhang LY, Wang H, Ye WC. Steroidal saponins and ecdysterone from Asparagus filicinus and their cytotoxic activities. Steroids. 2010 Oct;75(10):734-9. doi: 10.1016/j.steroids.2010.05.002. Epub 2010 May 12. PubMed PMID: 20470812. 3: Ding Y, Yang CR. [Steroidal saponins from Asparagus filicinus]. Yao Xue Xue Bao. 1990;25(7):509-14. Chinese. PubMed PMID: 2085127.