Synonym
Phenopyrazone; Diphenox; DPHP;
IUPAC/Chemical Name
1,4-Diphenylpyrazolidine-3,5-dione
InChi Key
YQPSKWMIWSXMMH-QVZOYWDGSA-N
InChi Code
O=C(C1C2=CC=CC=C2)NN(C3=CC=CC=C3)C1=O
SMILES Code
1,4-Diphenylpyrazolidine-3,5-dione
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
252.27
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Schuff-Werner P, Berg PA. [Immune reactions in pseudo-lupus-syndrome. A long-term study (author's transl)]. Klin Wochenschr. 1980 Sep 15;58(18):935-41. German. PubMed PMID: 7206589.
2: Grob PJ, Müller-Schoop JW, Häcki MA, Joller-Jemelka HI. Drug-induced pseudolupus. Lancet. 1975 Jul 26;2(7926):144-8. PubMed PMID: 49743.
3: Nakamura H, Motoyoshi S, Shimizu M. [Combined effect of aminopyrine with phenopyrazone on analgesic, anti-pyretic and anti-inflammatory activities in experimental animals (author's transl)]. Yakugaku Zasshi. 1978 Jun;98(6):679-88. Japanese. PubMed PMID: 308535.
4: De Groote J. [Mitochondrial antigens and their antibodies]. Acta Gastroenterol Belg. 1991 Jan-Feb;54(1):19-26. Review. Dutch. PubMed PMID: 2058346.
5: Wollina U. [Drug-induced lupus erythematosus syndrome. Pathogenesis and relation to systemic lupus erythematosus]. Z Gesamte Inn Med. 1984 Mar 1;39(5):69-73. German. PubMed PMID: 6719963.
6: Wälli F, Grob PJ, Müller-Schoop J. [Pseudo-(venocuran-)lupus--a minor episode in the history of medicine]. Schweiz Med Wochenschr. 1981 Sep 19;111(38):1398-405. German. PubMed PMID: 7280640.
7: Maas D, Schubothe H, Schramm A, Droese M, Adelung W, Winter H. [Mitochondrial antibodies induced by drug administration in patients with and without pseudo LE syndrome (author's transl)]. Immun Infekt. 1975 Dec;3(6):257-63. German. PubMed PMID: 1205499.
8: van Kerckhove C, Glass DN. The immunoglobulin supergene family and the polygenic nature of inherited predisposition to rheumatic disease. Arthritis Rheum. 1987 Aug;30(8):951-3. PubMed PMID: 3498495.
9: BLANK K. [On prolonged treatment of venous diseases with Venopyronum L drops]. Med Monatsschr. 1963 May;17:312-3. German. PubMed PMID: 13971505.
10: LEHMANN F. [On the treatment of ulcus cruris and varicose eczema with Venopyronum-L drops]. Ther Ggw. 1963 Jun;102:714-9. German. PubMed PMID: 13929346.
11: Grosse-Wilde H, Genth E, Grevesmühl A, Vögeler U, Zarnowski H, Mierau R, Doxiadis G, Doxiadis I, Maas D. HLA-DR4 and Gm 1;21 haplotypes are associated with pseudolupus induced by venopyronum dragées. Arthritis Rheum. 1987 Aug;30(8):878-83. PubMed PMID: 3498493.
