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MedKoo Cat#: 461827 | Name: Pericyclivine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pericyclivine is a catharanthus alkaloid from Catharanthus roseus.

Chemical Structure

Pericyclivine
CAS#975-77-9

Theoretical Analysis

MedKoo Cat#: 461827

Name: Pericyclivine

CAS#: 975-77-9

Chemical Formula: C20H22N2O2

Exact Mass: 322.1681

Molecular Weight: 322.40

Elemental Analysis: C, 74.51; H, 6.88; N, 8.69; O, 9.92

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Pericyclivine;
IUPAC/Chemical Name
methyl (6S,7R,10R,11aS,E)-9-ethylidene-5,6,8,9,10,11,11a,12-octahydro-6,10-methanoindolo[3,2-b]quinolizine-11-carboxylate
InChi Key
VXRAIAAMNNTQES-PEMUAGBOSA-N
InChi Code
InChI=1S/C20H22N2O2/c1-3-11-10-22-16-9-14-12-6-4-5-7-15(12)21-19(14)17(22)8-13(11)18(16)20(23)24-2/h3-7,13,16-18,21H,8-10H2,1-2H3/b11-3-/t13-,16-,17-,18?/m0/s1
SMILES Code
O=C(C1[C@]2([H])/C(C[N@]3[C@](C2)([H])C(NC4=C5C=CC=C4)=C5C[C@@]13[H])=C\C)OC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 322.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: FARNSWORTH NR, LOUB WD, BLOMSTER RN, GORMAN M. PERICYCLIVINE, A NEW CATHARANTHUS ALKALOID. J Pharm Sci. 1964 Dec;53:1558. PubMed PMID: 14255153. 2: Mukhopadhyay S, Cordell GA. Catharanthus alkaloids. XXXVI. Isolation of vincaleukoblastine (VLB) and periformyline from Catharanthus trichophyllus and pericyclivine from Catharanthus roseus. J Nat Prod. 1981 May-Jun;44(3):335-9. PubMed PMID: 7264682. 3: Kingston DG, Gerhart BB, Ionescu F, Mangino MM, Sami SM. Plant anticancer agents V: new bisindole alkaloids from Tabernaemontana johnstonii stem bark. J Pharm Sci. 1978 Feb;67(2):249-51. PubMed PMID: 621649. 4: van der Heijden R, Hermans-Lokkerbol A, de Kool LP, Lamping PJ, Harkes PA, Verpoorte R. Accumulation of indole alkaloids in a suspension culture of Tabernaemontana divaricata. Planta Med. 1988 Oct;54(5):393-7. PubMed PMID: 17265301. 5: Kingston DG, Li BT, Ionescu F. Plant anticancer agents III: Isolation of indole and bisindole alkaloids from Tabernaemontana holstii roots. J Pharm Sci. 1977 Aug;66(8):1135-8. PubMed PMID: 561182.