MedKoo Cat#: 558585 | Name: Cotarnine chloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cotarnine chloride is a oxidative degradation product of the drug Noscapine.

Chemical Structure

Cotarnine chloride
Cotarnine chloride
CAS#10018-19-6

Theoretical Analysis

MedKoo Cat#: 558585

Name: Cotarnine chloride

CAS#: 10018-19-6

Chemical Formula: C12H14ClNO3

Exact Mass: 255.0700

Molecular Weight: 255.70

Elemental Analysis: C, 56.37; H, 5.52; Cl, 13.86; N, 5.48; O, 18.77

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Synonym
Cotarnine chloride; Cotarnine Cl; Stypticin; Cotarninium chloride; Kotarninchlorid; NSC-24824; NSC24824; NSC 24824
IUPAC/Chemical Name
4-methoxy-6-methyl-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinolin-6-ium chloride
InChi Key
BWQAGVANIBSWBW-UHFFFAOYSA-M
InChi Code
InChI=1S/C12H14NO3.ClH/c1-13-4-3-8-5-10-12(16-7-15-10)11(14-2)9(8)6-13;/h5-6H,3-4,7H2,1-2H3;1H/q+1;/p-1
SMILES Code
C[N+]1=CC2=C(OC)C(OCO3)=C3C=C2CC1.[Cl-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 255.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Suprun PP. [Iodometric methods for the control of cotarnine chloride based on the polyiodide reaction]. Farm Zh. 1976 Jul-Aug;(4):39-43. Ukrainian. PubMed PMID: 1001419. 2: Tsukanov IuV, Brutko LI, Polievktov MK. [Polarographic determination of cotarnine chloride in tablets]. Farmatsiia. 1975 Nov-Dec;24(6):77-8. Russian. PubMed PMID: 1218634. 3: Anh LT, Titov AA, Samavati R, Voskressensky LG, Varlamov AV, Khrustalev VN. A new approach to alkaloid-like systems: synthesis and crystal structure of 1-(2-acetyl-11-meth-oxy-5,6-di-hydro-[1,3]dioxolo[4,5-g]pyrrolo-[2,1-a]isoquinoli n-1-yl)propan-2-one. Acta Crystallogr E Crystallogr Commun. 2017 Oct 20;73(Pt 11):1732-1734. doi: 10.1107/S2056989017015110. eCollection 2017 Nov 1. PubMed PMID: 29152361; PubMed Central PMCID: PMC5683501.