MedKoo Cat#: 558566 | Name: Strophanthin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Strophanthin inhibits free-radical oxidation of o-dianisidine via binding to the enzyme-substrate complex, preventing the generation of a stable semi-oxidized product of o-dianisidine, and thus inhibiting the enzyme by the anticompetitive mechanism. Mechanisms of oxidation of slowly and rapidly oxidizable substrates of peroxidase in the presence of strophanthin G are suggested.

Chemical Structure

Strophanthin
Strophanthin
CAS#11005-63-3

Theoretical Analysis

MedKoo Cat#: 558566

Name: Strophanthin

CAS#: 11005-63-3

Chemical Formula: C39H60O13

Exact Mass: 736.4000

Molecular Weight: 736.90

Elemental Analysis: C, 63.57; H, 8.21; O, 28.22

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Strophanthin; Kombetin; Eustrophinum; Combetin; STROPHANTHIN K,
IUPAC/Chemical Name
(3S,5S,8R,9S,10S,13R,14S,17R)-5,14-dihydroxy-3-(((4R,6R)-4-methoxy-6-methyl-5-(((1S,2S,3R,4S,5S)-2,3,4-trihydroxy-5-(hydroxymethyl)cyclohexyl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-8,9,13-trimethyl-17-(5-oxo-2,5-dihydrofuran-3-yl)hexadecahydro-10H-cyclopenta[a]phenanthrene-10-carbaldehyde
InChi Key
OBAGDHZPZLEISV-TXZACQIRSA-N
InChi Code
InChI=1S/C39H60O13/c1-21-33(52-26-14-22(18-40)30(43)32(45)31(26)44)27(48-5)16-29(50-21)51-24-6-8-37(20-41)35(3)11-10-34(2)25(23-15-28(42)49-19-23)7-9-39(34,47)36(35,4)12-13-38(37,46)17-24/h15,20-22,24-27,29-33,40,43-47H,6-14,16-19H2,1-5H3/t21-,22+,24+,25-,26+,27-,29?,30+,31-,32-,33?,34-,35+,36-,37+,38+,39+/m1/s1
SMILES Code
C[C@@H]1C(O[C@H]2C[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](OC)CC(O[C@H]3CC[C@]4(C=O)[C@@]5(C)CC[C@]6(C)[C@@H](C7=CC(OC7)=O)CC[C@@]6(O)[C@]5(C)CC[C@]4(O)C3)O1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 736.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Aslanian NL, Samvelian VM, Gasparian GS. Chronopharmacology of strophanthin and inderal: an experimental study. Cor Vasa. 1990;32(5):421-31. PubMed PMID: 2286091. 2: Rogozhin VV, Rogozhina TV. Effect of strophanthin G on peroxidase oxidation kinetics of slowly oxidizable peroxidase substrates. Biochemistry (Mosc). 2000 May;65(5):558-64. PubMed PMID: 10851032. 3: Karsanov NV, Sukoian GV, Tatulashvili DR, Karsanov VN, Mamulashvili LD. [Differences in mechanisms of action of beta-acetyldigoxin, strophanthin K and ouabain]. Biull Eksp Biol Med. 1992 Feb;113(2):146-9. Russian. PubMed PMID: 1611058. 4: RISING JD. Digitalis glycosides, ouabain and strophanthin in general practice. J Kans Med Soc. 1948 Jan;49(1):14-9. PubMed PMID: 18897678. 5: DORNER J. [Experimental studies on the peroral efficacy of strophanthin (strophoral), with a contribution on the mode of action of toxic doses of strophanthin]. Z Kreislaufforsch. 1951 Jul;40(13-14):393-415. Undetermined Language. PubMed PMID: 14867532. 6: HOCKERTS T. [Research on the cellular metabolism of the sufficient and insufficient myocardium and its control by strophanthin]. Monatsschr Kinderheilkd. 1961 Mar;109:101-2. German. PubMed PMID: 13714814. 7: Storz H. [On the quantitative effectiveness of k-strophanthin-alpha (Cymarin) in intravenous and oral administration]. Dtsch Med Wochenschr. 1969 May 30;94(22):1166-9. German. PubMed PMID: 5768542. 8: BLUMBERGER K. [Strophanthin; review of old theories]. Med Monatsschr. 1956 Apr;10(4):224-31. German. PubMed PMID: 13333632. 9: VON BOHM E. [Small single doses of strophanthin combined with honey solutions in intravenous therapy of heart disease]. Ther Ggw. 1955 Sep;94(9):344-5. German. PubMed PMID: 13291276. 10: Kochetygov NI, Bulavich ON. [Cardiac output and oxygen consumption during treatment of burn shock with rheopolyglucin and strophanthin]. Patol Fiziol Eksp Ter. 1978 Sep-Oct;(5):41-5. Russian. PubMed PMID: 733333. 11: FOERSTER W, SZIEGOLEIT W. [ON THE ACUTE AND SUBACUTE TOXICITY OF CONVALLATOXOL IN COMPARISON WITH CONVALLATOXIN AND G-STROPHANTHIN]. Acta Biol Med Ger. 1964;12:434-42. German. PubMed PMID: 14134947. 12: Zeng YC, Jin ZJ, Gu PK. Retinal toxicity in albino rabbits induced by intravitreal injection of strophanthin-K. J Ocul Pharmacol. 1990 Spring;6(1):51-60. PubMed PMID: 2362160. 13: KRAUPP O, OBENAUS H, PILLAT B, STUMPF C. [The dependence of the lethal dose on infusion speed as illustrated by g-strophanthin and thevetin B]. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1959;237:388-400. German. PubMed PMID: 14411766. 14: Fan-Tkhi-Ngok-Shiong. [Electroca rdiographic control in clinical use of mean therapeutic doses of cardiac glycosides (strophanthin, corglycon)]. Ter Arkh. 1974;46(6):83-9. Russian. PubMed PMID: 4473844. 15: SOLTI F, REV J, MARTON I, KOLTAY E. The effect of strophanthin on the secretion of sweat. Acta Med Acad Sci Hung. 1958;12(3-4):299-304. PubMed PMID: 13649243. 16: Lemkina SM. [Effect of isoptin on toxic and cardiotonic effect of strophanthin K]. Kardiologiia. 1993;33(5):37-40. Russian. PubMed PMID: 7967327. 17: FARAH A. On the elimination of g-strophanthin by the rat. J Pharmacol Exp Ther. 1946 Mar;86:248-57. PubMed PMID: 21020046. 18: NAYLER WG. The effect of strophanthin-G on the rate of deamination of adenyl compounds. Aust J Exp Biol Med Sci. 1959 Apr;37:109-16. PubMed PMID: 14426248. 19: Chernysh IN, Sadovnikov VB. [The effect of the glycoside strophanthin K on the ultrastructure of the cardiomyocytes in the pro-oxidant zone of the myocardium in rats with experimental heart failure]. Eksp Klin Farmakol. 1997 Jul-Aug;60(4):29-31. Russian. PubMed PMID: 9376752. 20: KERN B. [Demonstration of the resorption of strophanthin]. Med Monatsschr. 1952 Jun;6(6):371-4. Undetermined Language. PubMed PMID: 12982528.