Synonym
Cyclohexanediamine tetraacetic acid; Komplexon IV; Complexon IV;
IUPAC/Chemical Name
(1,2-Cyclohexylenedinitrilo)tetraacetic acid
InChi Key
FCKYPQBAHLOOJQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H22N2O8/c17-11(18)5-15(6-12(19)20)9-3-1-2-4-10(9)16(7-13(21)22)8-14(23)24/h9-10H,1-8H2,(H,17,18)(H,19,20)(H,21,22)(H,23,24)
SMILES Code
O=C(O)CN(CC(O)=O)C1C(N(CC(O)=O)CC(O)=O)CCCC1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
346.34
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Xie J, Funakoshi T, Shimada H, Kojima S. Effects of chelating agents on testicular toxicity in mice caused by acute exposure to nickel. Toxicology. 1995 Dec 10;103(3):147-55. PubMed PMID: 8553358.
2: Misra M, Athar M, Hasan SK, Srivastava RC. Alleviation of nickel-induced biochemical alterations by chelating agents. Fundam Appl Toxicol. 1988 Aug;11(2):285-92. PubMed PMID: 3220207.
3: Xie J, Funakoshi T, Shimada H, Kojima S. Comparative effects of chelating agents on pulmonary toxicity of systemic nickel in mice. J Appl Toxicol. 1996 Jul-Aug;16(4):317-24. PubMed PMID: 8854218.
4: Jarvis MC. The proportion of calcium-bound pectin in plant cell walls. Planta. 1982 May;154(4):344-6. doi: 10.1007/BF00393913. PubMed PMID: 24276162.
5: Kakegawa K, Ishii T, Matsunaga T. Effects of boron deficiency in cell suspension cultures of Populus alba L. Plant Cell Rep. 2005 Jan;23(8):573-8. Epub 2004 Sep 29. PubMed PMID: 15455258.
6: Fujita H, Sasaki D, Fukuda K, Ishiwata S. Myosin light chain 2 modulates MgADP-induced contraction in rabbit skeletal and bovine cardiac skinned muscle. J Physiol. 2002 Jul 1;542(Pt 1):221-9. PubMed PMID: 12096063; PubMed Central PMCID: PMC2290394.
7: Xie J, Funakoshi T, Shimada H, Kojima S. Effects of chelating agents on tissue distribution and excretion of nickel in mice. Res Commun Mol Pathol Pharmacol. 1994 Nov;86(2):245-55. PubMed PMID: 7881873.
8: Trosper TL, Philipson KD. Stimulatory effect of calcium chelators on Na+-Ca2+ exchange in cardiac sarcolemmal vesicles. Cell Calcium. 1984 Jun;5(3):211-22. PubMed PMID: 6434186.
9: Fujita T, Takata S, Sunahara Y. Enzymatic rate assay of creatinine in serum and urine. Clin Chem. 1993 Oct;39(10):2130-6. PubMed PMID: 8403398.
10: Yamada S, Umika F, Nakamura M, Nakamura S. Catalytic effect of some inorganic ligands on a ligand substitution reaction involving mercury(II) and its application as a differential kinetic method of analysis. Talanta. 1996 Oct;43(10):1715-20. PubMed PMID: 18966657.
11: Edashige Y, Ishii T. Hemicellulosic polysaccharides from bamboo shoot cell-walls. Phytochemistry. 1998 Nov 20;49(6):1675-1682. PubMed PMID: 11711080.
12: Chao SH, Bu CH, Cheung WY. Activation of troponin C by Cd2+ and Pb2+. Arch Toxicol. 1990;64(6):490-6. PubMed PMID: 2148867.
13: Hatakenaka M, Ohtsuki I. Effect of removal and reconstitution of troponins C and I on the Ca(2+)-activated tension development of single glycerinated rabbit skeletal muscle fibers. Eur J Biochem. 1992 May 1;205(3):985-93. PubMed PMID: 1577014.
14: Liang XS, Liu C, Long Z, Guo XH. Rapid and simple detection of endospore counts in probiotic Bacillus cultures using dipicolinic acid (DPA) as a marker. AMB Express. 2018 Jun 19;8(1):101. doi: 10.1186/s13568-018-0633-0. PubMed PMID: 29922919; PubMed Central PMCID: PMC6008271.
