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MedKoo Cat#: 461785 | Name: Saponarin
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Saponarin is a flavone glucoside isolated from Gypsophila trichotoma Wend. that has antioxidant and hepatoprotective activities.

Chemical Structure

Saponarin
Saponarin
CAS#20310-89-8

Theoretical Analysis

MedKoo Cat#: 461785

Name: Saponarin

CAS#: 20310-89-8

Chemical Formula: C27H30O15

Exact Mass: 594.1585

Molecular Weight: 594.52

Elemental Analysis: C, 54.55; H, 5.09; O, 40.37

Price and Availability

Size Price Availability Quantity
5mg USD 380.00 2 Weeks
10mg USD 720.00 2 Weeks
25mg USD 1,350.00 2 Weeks
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Related CAS #
No Data
Synonym
Saponarin;
IUPAC/Chemical Name
5-hydroxy-2-(4-hydroxyphenyl)-6-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one
InChi Key
HGUVPEBGCAVWID-KETMJRJWSA-N
InChi Code
InChI=1S/C27H30O15/c28-7-15-19(32)22(35)24(37)26(40-15)18-14(41-27-25(38)23(36)20(33)16(8-29)42-27)6-13-17(21(18)34)11(31)5-12(39-13)9-1-3-10(30)4-2-9/h1-6,15-16,19-20,22-30,32-38H,7-8H2/t15-,16-,19-,20-,22+,23+,24-,25-,26+,27-/m1/s1
SMILES Code
O=C1C=C(C2=CC=C(O)C=C2)OC3=C1C(O)=C([C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4)C(O[C@H]5[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O5)=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 594.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Contreras RA, Pino C, Riveros G, Cortés X, Cidral-Christ A, Zúñiga GE. Inhibition of Key Virulence Enzymes of Botrytis cinerea by Flavonoids from the Antarctic Plant Colobanthus quitensis. Chem Biodivers. 2024 Sep 26:e202401445. doi: 10.1002/cbdv.202401445. Epub ahead of print. PMID: 39325994. 2: Neuhauser C, Schwarzinger B, Schwarzinger C, Feichtinger M, Stadlbauer V, Arnaut V, Drotarova I, Blank-Landeshammer B, Weghuber J. Insulin-Mimetic Activity of Herbal Extracts Identified with Large-Scale Total Internal Reflection Fluorescence Microscopy. Nutrients. 2024 Jul 9;16(14):2182. doi: 10.3390/nu16142182. PMID: 39064624; PMCID: PMC11280383. 3: Kim SH, Shim YY, Kim YJ, Reaney MJT, Chung MJ. Anti-Inflammatory Effects of Barley Sprout Fermented by Lactic Acid Bacteria in RAW264.7 Macrophages and Caco-2 Cells. Foods. 2024 Jun 6;13(11):1781. doi: 10.3390/foods13111781. PMID: 38891009; PMCID: PMC11172312. 4: Vishnupriya N, Sankar MM, Vimal S, Radhakrishnan N. STITCH and Molecular Docking Analysis of Selected Wood Apple (Limonia acidissima) Constituents as Anti-Dandruff and Anti-Acne Agents. J Pharm Bioallied Sci. 2024 Apr;16(Suppl 2):S1167-S1172. doi: 10.4103/jpbs.jpbs_508_23. Epub 2024 Apr 16. PMID: 38882809; PMCID: PMC11174285. 5: Lee DY, Kang SW, Kim JS, Bae JY, Lee HL, Lee H, Seo WD, Jang YS, Kim JH. Effect of Abiotic Signals on the Accumulation of Saponarin in Barley Leaves in Hydroponics Under Artificial Lights. ACS Omega. 2024 Feb 21;9(9):10852-10859. doi: 10.1021/acsomega.3c09809. PMID: 38463256; PMCID: PMC10918822. 6: Boyina R, Kosanam S, Bhimana S, Gudimitla RB, Duraiswamy D. In-vitro and In Silico Assessment of Anti-inflammation Properties of Saponarin Extracted from Hordeum Vulgare. Antiinflamm Antiallergy Agents Med Chem. 2024;23(1):14-20. doi: 10.2174/0118715230284334240101100450. PMID: 38258776. 7: Yoon YE, Cho JY, Kim YN, Kantharaj V, Lee KA, Seo WD, Lee YB. Variation of Saponarin Content in Barley Sprouts (Hordeum vulgare L.) by Natural Light Shielding: Implication of the Importance of Light Intensity. ACS Omega. 2023 Sep 20;8(39):35837-35844. doi: 10.1021/acsomega.3c03458. PMID: 37810714; PMCID: PMC10552494. 8: Bing Y, Sun Z, Wu S, Zheng Y, Xi Y, Li W, Zou X, Qu Z. Discovery and verification of Q-markers for promoting blood circulation and removing stasis of raw and wine-steamed Vaccaria segetalis based on pharmacological evaluation combined with chemometrics. J Ethnopharmacol. 2024 Jan 30;319(Pt 1):117120. doi: 10.1016/j.jep.2023.117120. Epub 2023 Sep 2. PMID: 37666377. 9: Wang YY, Li Q, Han XW, Wan XH, Zhang L, Niu FJ, Xin YZ, Zhou CZ. Bryum billardieri Schwaegr. against EV71 infection: in vitro and in vivo antiviral effects, identification of molecular mechanisms and active monomers. Front Pharmacol. 2023 Aug 15;14:1164784. doi: 10.3389/fphar.2023.1164784. PMID: 37649892; PMCID: PMC10463183. 10: Saeid Nia M, Scholz L, Garibay-Hernández A, Mock HP, Repnik U, Selinski J, Krupinska K, Bilger W. How do barley plants with impaired photosynthetic light acclimation survive under high-light stress? Planta. 2023 Aug 26;258(4):71. doi: 10.1007/s00425-023-04227-8. PMID: 37632541; PMCID: PMC10460368. 11: Kantharaj V, Yoon YE, Lee KA, Choe H, Chohra H, Seo WD, Kim YN, Lee YB. Saponarin, a Di-glycosyl Flavone from Barley (Hordeum vulgare L.): An Effective Compound for Plant Defense and Therapeutic Application. ACS Omega. 2023 Jun 14;8(25):22285-22295. doi: 10.1021/acsomega.3c00267. PMID: 37396229; PMCID: PMC10308553. 12: Villada Ramos JA, Aguillón Osma J, Restrepo Cortes B, Loango Chamarro N, Maldonado Celis ME. Identification of potential bioactive compounds of Passiflora edulis leaf extract against colon adenocarcinoma cells. Biochem Biophys Rep. 2023 Mar 28;34:101453. doi: 10.1016/j.bbrep.2023.101453. PMID: 37009402; PMCID: PMC10063390. 13: Supriya S, Ushikoshi-Nakayama R, Yamazaki T, Omagari D, Aota K, Inoue H, Matsumoto N, Saito I. Effects of polyphenols in non-centrifugal cane sugar on saliva secretion: in vitro and in vivo experiments and a randomized controlled trial. J Clin Biochem Nutr. 2023 Mar;72(2):171-182. doi: 10.3164/jcbn.22-114. Epub 2022 Dec 28. PMID: 36936876; PMCID: PMC10017321. 14: Matłok N, Piechowiak T, Kapusta I, Królikowski K, Balawejder M. Induction of Biosynthesis Antioxidant Molecules in Young Barley Plants by Trioxygen. Molecules. 2022 Oct 24;27(21):7195. doi: 10.3390/molecules27217195. PMID: 36364021; PMCID: PMC9656088. 15: Yu GR, Lim DW, Karunarathne WAHM, Kim GY, Kim H, Kim JE, Park WH. A non- polar fraction of Saponaria officinalis L. acted as a TLR4/MD2 complex antagonist and inhibited TLR4/MyD88 signaling in vitro and in vivo. FASEB J. 2022 Jul;36(7):e22387. doi: 10.1096/fj.202200018RR. PMID: 35696068. 16: Sati D, Joshi T, Pandey SC, Pande V, Mathpal S, Chandra S, Samant M. Identification of Putative Elicitors From Plant Root Exudates Responsible for PsoR Activation in Plant-Beneficial Pseudomonas spp. by Docking and Molecular Dynamics Simulation Approaches to Decipher Plant-Microbe Interaction. Front Plant Sci. 2022 Apr 6;13:875494. doi: 10.3389/fpls.2022.875494. PMID: 35463415; PMCID: PMC9020294. 17: Klem K, Oravec M, Holub P, Šimor J, Findurová H, Surá K, Veselá B, Hodaňová P, Jansen MAK, Urban O. Interactive effects of nitrogen, UV and PAR on barley morphology and biochemistry are associated with the leaf C:N balance. Plant Physiol Biochem. 2022 Feb 1;172:111-124. doi: 10.1016/j.plaphy.2022.01.006. Epub 2022 Jan 13. PMID: 35063862. 18: Kim HJ, Lim S, Chung S, Lee S, Choi E, Yang KH, Hwang JT, Chung MY. Barley Sprout Water Extract and Saponarin Mitigate Triacylglycerol Accumulation in 3T3-L1 Adipocytes. J Med Food. 2022 Jan;25(1):79-88. doi: 10.1089/jmf.2021.K.0092. PMID: 35029509. 19: Kim YR, Lee SY, Lee SM, Shim I, Lee MY. Effect of Hibiscus syriacus Linnaeus extract and its active constituent, saponarin, in animal models of stress- induced sleep disturbances and pentobarbital-induced sleep. Biomed Pharmacother. 2022 Feb;146:112301. doi: 10.1016/j.biopha.2021.112301. Epub 2021 Dec 13. PMID: 34915415. 20: Kim IS, Hwang CW, Yang WS, Kim CH. Multiple Antioxidative and Bioactive Molecules of Oats (Avena sativa L.) in Human Health. Antioxidants (Basel). 2021 Sep 13;10(9):1454. doi: 10.3390/antiox10091454. PMID: 34573086; PMCID: PMC8471765.

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